摘要
心房颤动(房颤)是临床上最常见的心律失常,房颤及其并发症是导致心血管疾病发病和死亡的重要因素。虽然近年来的研究对于房颤的发生、维持和进展的病理生理机制有了很多新认识,但仍有许多尚未弄清。目前认为房颤的病理生理机制主要包括电重构、结构重构、自主神经系统功能改变和Ca2+调控异常4个方面,由此也提出了一些学说。本述评将对这方面的当前认识作扼要介绍。
Atrial fibrillation（AF）is the most common sustained arrhythmia in clinical practice.AF and its complications are responsible for the population morbidity and mortality in cardiovascular disease.Recent research has identified a multitude of pathophysiological mechanisms related to the initiation,maintenance,and progression of AF.However,many aspects of AF pathophysiology remain incompletely understood.Presently,it is agreed that there are 4principal pathophysiological mechanisms contributing to AF,including electrical remodeling,structural remodeling,autonomic nervous system changes,and Ca2＋handling abnormalities.Some hypotheses of AF have been put forward based on these mechanisms.This report reviews recent advances in the understanding of basic pathophysiology of AF.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2015年第3期231-233,共3页
Journal of Clinical Cardiology
基金
国家自然科学基金(No:81370306
81170164)
关键词
心房颤动
电重构
结构重构
自主神经系统功能改变
Ca2+调控异常
atrial fibrillation
electrical remodeling
structural remodeling
autonomic nervous system changes
Ca2＋handling abnormalities
