头孢克肟、夫西地酸对小儿外科耐药金黄色葡萄球菌感染疗效研究

Research on the efficacy of cefminox combined with fusidinic treatment of staphylococcus aureus infection in patients of pediatric surgery

目的分析头孢克肟联合夫西地酸治疗小儿外科耐药金黄色葡萄球菌感染患者的效果。方法以收治的78例小儿外科耐药金黄色葡萄球菌感染患者为对象开展研究,按随机数字表法将其均分为对照组与观察组,对照组患者仅进行头孢克肟进行治疗;观察组患者在此基础上联合使用夫西地酸进行治疗。2周之后统计患者治疗总有效率和耐药发症率,进行对比分析。结果 (1)经过治疗后,观察组的治疗总有效率为94.9%(37/39),明显优于对照组76.9%(30/39),差异有统计学意义(P<0.05);(2)观察组出现2例耐药发症,对照组仅1例,但组间差异无统计学意义(P>0.05);(3)观察组胸腔积水治疗总有效率高达81.8%,显著优于对照组的27.2%,差异有统计学意义(P<0.05)。结论在头孢克肟的基础上,对小儿外科耐药金黄色葡萄球菌肺炎患者配合使用夫西地酸,不仅不会提升耐药发症率,还能有效提高治疗效果,值得推广。

Objective To analyze the efficacy of cefminox combined with fusidinic in the treatment of staphylococcus aureus infection in patients of pediatric surgery. Methods 78 patients of pediatric surgery with staphylococcus aureus infection, who were selected as the research objects, were randomly divided into control group who were treated with cefminox and observation group who were treated with cefminox combined fusidinic. To comparatively analyze the treatment total effective rate and the resistance incidence of patients after two weeks. Results（1）After treatment, the treatment total effective rate in observation group of 94.9%（37/39）was obviously better than which in control group of 76.9%（30/39）, the difference was statically significant（P〈0.05）.（2）There were 2 cases of resistance occurred in observation group, but 1 case of resistance occurred in control group, the difference was statically significant（P〈0.05）.（3）The hydrothorax total effective rate in observation group of 81.8% was obviously better than which in control group of 27.2%, the difference was statically significant（P〈0.05）. Conclusion Cefminox combined with fusidinic in the treatment of staphylococcus aureus infection in patients of pediatric surgery not only will not improve the resistance incidence, but also could improve the treatment effect, is worthy of clinical popularization.