芬吗通在稽留流产刮宫术后应用的临床观察

Application of Femoston after missed abortion curettage Femoston

目的观察芬吗通用于稽留流产刮宫术后的临床效果。方法选择2012年1月至2014年3月在我集团妇科住院的稽留流产患者160例,随机分为观察组(80例)和对照组(80例)。观察组刮宫术后当天开始口服芬吗通,1片·次-1·d-1,共28d。对照组仅进行常规处理,未服用芬吗通。比较两组患者术后阴道流血量、流血时间、首次月经恢复时间、术后14d子宫内膜厚度、并发症发生情况等。结果观察组术后阴道流血时间(3.0±1.4)d,短于对照组的(6.2±1.6)d,差异有统计学意义(P<0.05);观察组术后14d子宫内膜厚度(7.20±1.54)mm,显著厚于对照组的(4.63±1.65)mm,差异有统计学意义(P<0.05);观察组术后月经如期恢复率(98.75%)显著高于对照组(71.25%),差异有统计学意义(P<0.05);观察组术后宫腔积液、宫颈粘连发生率(分别为1.25%和1.25%)亦显著低于对照组(分别为7.50%和3.75%),差异有统计学意义(P<0.05)。结论稽留流产妇女刮宫术后口服芬吗通有利于子宫内膜修复及恢复正常月经周期,能有效预防宫腔粘连,且服用简单、方便,值得临床推广应用。

Objective：To observe the clinic effect of administering Femoston after missed abortion curettage.Methods：One hundred and sixty patients with missed abortion curettage in Qingdao Hiser Hospital between January 2012 and March 2014 were divided into two groups.The patients in the study group orally received one tablet Femoston for 28 days,and the patients in control group did not receive Femoston.Results：The vaginal bleeding duration [（3.0±1.4）vs.（6.2±1.6）days ]in the study group was significantly shorter than that than that in the control group（P0.05）.The thickness of endometrium in the study group[（7.20±1.54）vs.（4.63±1.65）mm]was significantly thicker than that of the control group（P 0.05）.The rate of resumption of normal menstruation（98.76%）in the study group was significantly higher（71.25%）than that in the control group（P0.05）.The hydrohystera rate（1.25% vs.7.50%）and cervical adhesion rate（1.25% vs.3.75%）in the study group were significantly lower than those in the control group（P0.05）.Conclusions：Application of Femoston for the patients with missed abortion curettage has benefit for endometrial restoration,resumption of normal menstruation,prevention of intrauterine adhesion and amenorrhea.The method is worthy to promote for clinical application.