高危人工流产术后应用芬吗通预防宫腔粘连的临床观察

Application of Femoston in prevention of intrauterine adhesion after high-risk induced abortion

目的探讨高危人工流产术后应用芬吗通预防宫腔粘连(IUA)的临床疗效。方法将101例高危人工流产患者分为两组:治疗组48例,在临床常规处理基础上,人工流产术后当日起服用芬吗通,共28d;对照组53例,常规缩宫、预防感染治疗。观察对比两组患者术后阴道出血时间、子宫内膜修复情况及宫颈、宫腔粘连情况。结果治疗组术后阴道出血时间为(3.10±0.11)d,显著短于对照组(6.38±0.17)d,差异有统计学意义(P<0.05);治疗组术后14d子宫内膜厚度[(0.90±0.02)cm],较对照组[(0.49±0.02cm)]显著增厚,差异有统计学意义(P<0.05);治疗组1例发生宫腔、宫颈粘连,IUA发生率为2.08%(1/48),而对照组IUA发生率13.21%(7/53),治疗组显著低于对照组,差异有统计学意义(P<0.05)。结论高危人工流产术后给予芬吗通治疗不失为预防宫腔粘连的有效方法。

Objective：To explore the clinical effects of applying Femoston in preventing intrauterine adhesion after high-risk induced abortion.Methods：A total of 101 patients with high-risk induced abortion were divided into 2groups.The patients in treatment group（n=48）were given one tablet of Femoston per day for 28 days besides oxytocin and antibiotics after induced abortion.The patients in control group（n=53）were only given oxytocin and antibiotics.The duration of vaginal bleeding,endometrial repair status and the incidence of the intrauterine adhesion were compared between the two groups.Results：The duration vaginal bleeding [（3.10±0.11）vs.（6.38±0.17）days]was significantly shorter in the treatment group than that in the control group（P0.05）.The thickness of endometrinm after 14 days reparation in the treatment group [（0.90±0.02）vs.（0.49±0.02）cm]was significantly thicker that that in the control group（P0.05）.The incidence of postoperative intrauterine adhesion in the treatment group[2.08%（1/48）vs.13.21%（7/53）]was significantly lower than that in the control group（2χ=4.27,P0.05）.Conclusions：Immediate intake Femoston after high-risk induced abortion can significantly reduce the incidence of the intrauterine adhesion.Application of Femoston after high-risk induced abortion is an effective method for preventing intrauterine adhesion.