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绿茶提取物改善代谢综合征患者脂质代谢的meta分析 被引量:3

Green tea extract improves the lipid metabolism in patients with metabolic syndrome: a meta-analysis
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摘要 目的系统评价绿茶提取物改善代谢综合征患者脂质代谢的疗效和安全性。方法计算机检索中英文文献,收集绿茶提取物与代谢综合征患者脂质代谢相关的随机对照试验,采用RevMan5.2软件进行meta分析。结果纳入9篇随机对照研究文献,共566例代谢综合征患者。Meta分析结果显示,与安慰剂组相比,在治疗终点时绿茶提取物有效降低代谢综合征患者低密度脂蛋白胆固醇(LDL—C)水平[SMD=-0.33,95%CI(-0.56,-0.09),P=0.007],差异有统计学意义,高密度脂蛋白胆固醇[SMD=0.19,95%CU(-0.04,0.43),P=0.10]、总胆固醇[SMD=-0.13,95%CI(-0.39,0.13),P=0.33]及甘油三酯[SMD=-0.07,95%CI(-0.46,0.33),P=0.74]水平2组差异无统计学意义。绿茶提取物组和安慰剂组总体不良反应发生率差异无统计学意义[OR=0.97,95%CI(0.54,1.76),P=0.93]。结论绿茶提取物可有效降低代谢综合征患者LDL-C水平,且不良反应少。 Objective To systematically evaluate the efficacy and safety of green tea extract (GTE) in improving lipid metabolism in patients with metabolic syndrome (MS). Methods All relevant published articles in Chinese and English literature database were searched to collect the randomized controlled trials comparing the efficiency and safety of GTE in patients with MS. The meta-analysis was performed using RevMan 5.2 software. Results Nine studies involving 566 patients were included. The results of meta-analysis showed that: GTE significantly reduced the level of low-density lipoprotein cholesterol (LDL-C) (SMD =-0.33, 95% CI -0.56 --0.09, P = 0. 007 ) compared with placebo at the treatment endpoint. There were no statistical significance in high- density lipoprotein cholesterol ( SMD=0.19, 95% CI-0.04- 0.43, P = 0.10 ), total cholesterol ( SMD = -0.13, 95% CI-0.39 - 0.13, P = 0.33 ), and triglyceride ( SMD = -0.07, 95% CI -0.46 - 0.33, P = 0.74) levels between two groups. There was no significant difference in the overall rate of adverse events between two groups ( OR = 0.97,95 % CI 0. 54 - 1.76, P = 0.93 ). Conclusion GTE significantly reduces the level of LDL-C in patients with MS, and the adverse events were rare and mild.
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2015年第3期224-229,共6页 Chinese Journal of Endocrinology and Metabolism
基金 国家自然科学基金资助项目(81270169)
关键词 绿茶提取物 代谢综合征 脂质代谢 META分析 随机对照研究 Green tea extract Metabolic syndrome Lipid metabolism Meta-anaiysis Randomized controlled trial
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  • 1Efremov LI, Konev luV, Eazebnik LB, et al. Gluttony, obesity and the metabolic syndrome in the context of the "seven deadly sins". Historical-theological, literary and art, mass media, political, philosophical, medical-psychological and geriatric aspects of the omblemr J]. Ekso Klin Gastroenterol. 2013.4( 1 ) :93-98.
  • 2Canale MP, Manca di VS, Martino G, et al. Obesity-related metabolic syndrome: mechanisms of sympathetic overactivity [ J ]. Int J Endocrinol, 2013,2013:865965.
  • 3Dickson-Humphries T, Bottenberg B, Kuntz S. Lipoprotein abnormalities in patients with type 2 diabetes and metabolic syndrome [J]. JAAPA, 2013,26(7) :13-18.
  • 4Leao LS, de Moraes MM, de Carvalho GX, et al. Nutritional interventions in metabolic syndrome : a systematic review[ J]. Arquivos brasileiros de cardiologia, 2011,97 ( 3 ) :260-265.
  • 5Bogdanski P, Suliburska J, Szulinska M, et al. Green tea extract reduces blood pressure, inflammatory biomarkers, and oxidative stress and improves parameters associated with insulin resistance in obese, hypertensive patients[J]. Nutr Res, 2012,32(6) :421427.
  • 6Basu A, Du M, Sanchez K, et al. Green tea minimally affects biomarkers of inflammation in obese subjects with metabolic syndrome [J]. Nutrition, 2011,27(2) :206-213.
  • 7Brown AL, Lane J, Holyoak C, et al. Health effects of green tea catechins in overweight and obese men : a randomised controlled cross- over trial[ J]. Br J Nutr, 2011,106 (12) : 1880-1889.
  • 8Jadad AR, Moore RA, Carroll D, et al. Assessing the quality of reports of randomized clinical trials : is blinding necessary [ J ] ? Control Clin Trials, 1996,17 ( 1 ) : 1-12.
  • 9Higgins JPT, Green S ( editors ). Reviews of Interventions Version Cochrane Handbook for Systematic 5. 0. 1 [ updated March 2011 ] [ M ]. The Cochrane Collaboration, 2011. Available from www.
  • 10Di Pierro F, Menghi AB, Barreca A, et al. Greenselect phytosome as an adjunct to a low-calorie diet for treatment of obesity: a clinical trial [J]. Altem Med Rev, 2009,14(2) :154-160.

同被引文献34

  • 1中华医学会糖尿病学分会代谢综合征研究协作组.中华医学会糖尿病学分会关于代谢综合征的建议[J].中国糖尿病杂志,2004,12(3):156-161. 被引量:3060
  • 2万玉仑,陈开勇.联合应用电针和中药疏肝健脾活血方治疗代谢综合症的疗效分析[J].当代医药论丛,2014,12(2):151-152. 被引量:2
  • 3Lakka HM, Laaksonen DE, Lakka TA, et al. The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. JAMA, 2002,288 (21) :2709-2716.
  • 4Gallagher E J, Leroith D, Karnieli E. Insulin resistance in obesity as the underlying cause for the metabolic syndrome. Mt Sinai J Med, 2010,77 (5) :511-523.
  • 5Cheal KL, Abbasi F, Lamendola C, et al. Relationship to insulin resistance of the adult treatment panel III diagnostic criteria for identification of the metabolic syndrome. Diabetes, 2004,53 ( 5 ) : 1195- 1200.
  • 6Meigs JB, Rutter MK, Sullivan LM, et al. Impact of insulin resistance on risk of type 2 diabetes and cardiovascular disease in people with metabolic syndrome. Diabetes Care, 2007,30 (5) : 1219-1225.
  • 7Fall T, Ingelsson E. Genome-wide association studies of obesity and metabolic syndrome. Mol Cell Endocrinol, 2014,382 ( 1 ) :740-757.
  • 8Jiang X, Liu X, Wu S, et al. Metabolic syndrome is associated with and predicted by resting heart rate: a cross-sectional and longitudinal study. Heart, 2015,101 ( 1 ) :44-49.
  • 9Takahara M, Shimomura I. Metabolic syndrome and lifestyle modific- ation. Rev Endocr Metab Disord, 2014,15(4) :317-327.
  • 10Marco B, Anna CK, Patricia I, et al. Enhanced fatty acid uptake in visceral adipose tissueis not reversed by weight loss in obese individuals with the metabolic syndrome. Diabetologia, 2015,58 ( 1 ) :158-164.

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