2型糖尿病患者血清维生素D水平与甲状腺功能的关系研究

Relationship between thyroid function and serum vitamin D levels in type 2 diabetic patients

选取甲状腺自身抗体阴性的2型糖尿病患者180例，根据血25羟维生素D[25（OH）D]水平分为维生素D正常组（≥30ng／ml）18例、不足组（20-〈30ng／m1）34例、缺乏组（10～〈20ng／ml）46例及严重缺乏组（〈10ng／ml）82例。结果显示，维生素D严重缺乏组的TT3、FT3、FT33／FT4比值及TSH水平均明显高于维生素D正常组。经校正性别、年龄及体重指数后，血25（OH）D水平与TSH呈负相关（r=-0．207，P〈0．05）。多元线性回归分析显示血25（OH）D是预测TSH水平的独立危险因素（β=-0．201，P〈0．05），提示2型糖尿病患者的维生素D水平与甲状腺功能相关。

A total of 180 type 2 diabetic patients with negative anti-thyroid autoantibodies were recruited. According to the levels of serum 25-OH vitamin D [ 25 （ OH ） D ] , these patients were divided into four groups： sufficient group（ ≥30 ng/ml）, insufficient group（20-〈30 ng/ml） , deficiency group（ 10-〈20 ng/ml）, and severe deficiency group（ 〈10 ng/ml）. The results showed that compared with sufficient vitamin D group, the group with severe deficient vitamin D had higher TT3, FT3, FT3/FT4, and TSH （ all P〈0.05 ）. The serum 25 （OH） D level was negatively correlated with TSH values （ r = -0. 207, P〈0.05 ） after adjustment for gender, age, and body mass index. Multivariate regression analysis indicated that serum 25 （OH） D level was an independent influencing factor for TSH value （β = -0.201, P〈0.05 ）, suggesting that serum 25 （OH） D level seems to be correlated with thyroid function in type 2 diabetic patients.