摘要
目的研究金丝桃素在大鼠体内的组织分布。方法健康SD大鼠,单剂量尾静脉注射金丝桃素50mg·kg-1,并于给药后20,45,90min后采集大鼠心、肝、脾、肺、肾、胃、小肠,利用HPLC测定各组织中金丝桃素的浓度。结果大鼠尾静脉注射金丝桃素50mg·kg-1后,在肾脏中浓度较高,心脏中浓度较低。结论研究金丝桃素的组织分布特征可为该药的进一步研究开发和临床应用提供重要的参考依据。
OBJECTIVE To study the tissues distribution of hypericin in rats.METHODS A single dose of 50 mg·kg^-1 hypericin was administered to healthy SD rats via tail vein.The tissues of heart,liver,spleen,lung,kidney,stomach and small intestine were acquired at 20,45 or 90 min after administration.The concentrations of hypericin in tissues samples were determined by HPLC.RESULTS After a single tail vein dose of 50 mg·kg^-1 hypericin in rats,hypericin was mainly distributed in kidney.The concentrations of hypericin in heart was low.CONCLUSION This present investigation on hypericin tissues distribution provides important information to further study and clinic use of hypericin.
出处
《中国药学杂志》
CAS
CSCD
北大核心
2015年第7期602-605,共4页
Chinese Pharmaceutical Journal
基金
工业和信息化部中药材扶持资金项目(长白山道地药材生产技术公共服务平台建设)
