苦参碱-氮芥复合物的合成及抗肿瘤活性研究

Synthesis and Anti-cancer Activity of Matrine-nitrogen Mustard Compounds

根据拼合原理,以苦参碱和氮芥互为药效基团,合成了3种未见文献报道的标题化合物,采用MTT法测试目标化合物的体外抗肿瘤活性。目标化合物结构经1HNMR、MS和元素分析确证,且苦参碱-美法仑复合物和苦参碱-苯达莫司汀复合物均表现出较好的抗肿瘤活性。

In order to synthesize matrine derivatives and evaluate their in vitro anti-tumor activities. According to combination principles,three novel matrine-nitrogen mustard compounds were synthesized utilizing matrine and nitrogen mustard aspharma- cophore. And the in vitro anti-tumor activities were tested with MTT reduction assay. The structures of target compounds were characterized by elemental analysis, 1 HNMR and MS, The matrine-melphalan complex and matrine-bendamustine complex showed superior antitumor activity.