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有机催化不对称Henry反应研究进展

Progress in Asymmetric Organocatalytic Henry Reactions
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摘要 Henry是一个重要的人名反应,在有机合成中具有广泛的应用。分别概述了醛、酮化合物和硝基烷烃在有机小分子催化作用下的不对称Henry反应,以及有机催化的不对称串联Michael/Henry反应。对于胍、硫脲、胺、相转移催化剂及奎宁衍生物(类似物)等不同类型有机小分子催化不对称Henry反应作了概述。并对有机催化不对称Henry反应的研究作了相应的展望。 Henry reaction is an important name reaction,which is widely employed as a powerful C--C bond-forming tool in organ- ic syntheses. In this work,the asymmetric organocatalytic Henry reactions of aldehydes with nitroalkanes and the asymmetric or- ganoeatalytic Henry reactions of ketones with nitroalkanes were investigated, respectively. The enantioseleetive organocatalytic domino Michael/Henry reactions were also reviewed. The organoeatalysts engaged in the reactions could be guanidines,thioureas, amines, phase-transfer catalysts, quinine derivatives or analogues and so on. In addition, further research advances were expected.
出处 《化学试剂》 CAS 北大核心 2015年第4期319-324,共6页 Chemical Reagents
关键词 Henry反应 有机催化 不对称催化 立体选择性反应 串联反应 Henry reaction organocatalytic asymmetric catalytic enantioselective reaction domino reaction
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