Ki-67、P—gp在局部晚期宫颈癌组织中的表达及与新辅助化疗疗效的研究

Expression of Ki-67 and P-gp in locally advanced cervical cancer and their correlation study with the effect of neoadjuvant chemotherapy

目的分析局部晚期宫颈癌（LACC）组织中Ki-67、P糖蛋白（P-gp）的表达与新辅助化疗（NACT）疗效的关系，探讨二者的共表达性及临床病理意义。方法运用免疫组化法对53例LACC患者进行NACT前Ki-67、P-gp的表达量进行检测。结果53例LACC患者中有效32例（60．4％）。NACT疗效与Ki-67、P—gp的表达显著相关（P=0．006、0．029），Logistic回归显示Ki-67表达量越高、P—gp表达量越低，NACT越敏感（B=2．163、-3．39）。Spearman分析显示尚不能认为Ki-67与P—gp相关（P=0．325），且尚不能认为二者的共表达性与深肌层浸润、盆腔淋巴结转移相关（P=0．242、0．871）。结论NACT可用于LACC的治疗，Ki-67、P-gp可作为预测NACT疗效的指标。

Objective To study the correlation between expression of Ki-67, P-gp and effect of neoadjuvant chemotherapy（NACT） in locally advanced cervical cancer（LACC）, and to investigate coexpression of Ki-67, P-gp and its siginificance. Methods Fifty-three cases of LACC biopsy specimens before treatment were collected. Expression of Ki-67 and P-gp was analyzed with the technique of immu- nohistochemical staining. Results Thirty-two cases were effective among the total cases（60. 4% ）. There was siginificant correlation of the expression of Ki-67, p-gp with the effect of NACT （P = 0. 006, 0. 029）. High expression of Ki-67 and low expression of P-gp were positive factors for effect of NACT through results of the logistic regression （ β = 2. 163, - 3.39 ）. The results of the spearman corelations showed that there was no correlation of the expression of Ki-67 with P-gp（p =0. 325）. Co-expression of Ki-67, P-gp showed no relationship with deep stromal invasion and pelvic lymph node metastasis （p = 0. 242, 0. 871 ）. Conclusions NACT can be applied to treatment of LACC, and the expression of Ki-67 and P-gp are indicators of predicting the effect of NACT.