摘要
目的探讨替吉奥联合奥沙利铂治疗老年晚期胃癌的临床疗效。方法随机选取修武县人民医院2010年1月至2013年2月收治的老年晚期胃癌患者80例为研究对象，按入院顺序随机分为观察组和对照组，人数均等。观察组给予替吉奥联合奥沙利铂治疗，对照组给予替吉奥联合顺铂治疗，观察对比治疗两个疗程后两组的临床疗效、毒副反应发生率。结果观察组的总有效率（87．5％）与对照组（82．5％）相比差异未见统计学意义（P〉0．05）；观察组的毒副反应发生率（12．5％）明显低于对照组（35．0％），组间比较差异有统计学意义（P〈0．05）。结论替吉奥联合奥沙利铂治疗方案能显著改善老年晚期胃癌患者的症状，毒副作用相对较小，保障了患者的生活质量，值得临床推广。
Objective To investigate the clinical effect of TS-I combined with oxaliplatin on elderly patients with advanced gastric cancer. Methods Eighty elderly patients with advanced gastric cancer who were admitted in people＇ s hospital of Xiuwu from January 2010 to February 2013 were selected and divided into observation group and control group（40 cases in each group）, Observation group was given TS -1 combined with oxaliplatin for treatment and control group was given TS - 1 combined with cisplatin. The effects and adverse reactions occurrences of them were compared after two courses of treatment. Results The total effective rate was 87. 5% in observation group and 82. 5% in control group, but the difference was not significant （P 〉0. 05）. However, the incidence of adverse reaction in observation group （12. 5% ） was significant lower than that of control group（35.0% ,P 〈0. 05）. Conclusions TS - 1 combined with oxaliplatin can significantly improve the treatment effect on elderly patients with advanced gastric cancer symptoms, the adverse reactions were relatively less, therefore it is worthy to be promoted in clinics.
出处
《中国实用医刊》
2015年第8期30-31,共2页
Chinese Journal of Practical Medicine
