类风湿关节炎患者血清白细胞介素的检测及意义

Detection and significance of serum interleukins in patients with rheumatoid arthritis

目的探讨白细胞介素(IL)-6、IL-17、IL-23及类风湿因子(RF)、C-反应蛋白(CRP)在类风湿关节炎(RA)患者发病中的作用。方法采用流式液相多重蛋白定量技术(CBA)检测60例活动期RA患者和32例健康对照组血清中IL-6、IL-17、IL-23的水平,采用免疫比浊法检测RF及CRP水平。结果活动期RA患者血清中IL-6、IL-17、IL-23、RF、CRP的水平高于健康对照组,差异具有统计学意义(P<0.05)。RF与IL-17呈正相关。不同年龄组的RA患者之间,IL-17水平差异有统计学意义(P<0.05)。结论 IL-6、IL-17、IL-23、RF及CRP在RA的发病过程中起着重要的作用,IL-17可能成为临床诊断的潜在候选指标之一。

Objective To explore the roles of IL-6,IL-17,IL-23,and C-reactive protein（CRP）in the nosogenesis of rheumatoid arthritis（RA）.Methods Cytometric beads array（CBA）technology was used to detect the levels of IL-6,IL-17,IL-23 respectively in 60 cases of patients with active RA and 32 cases of healthy people（normal control group）,and the levels of rheumatoid factor（RF）and CRP in the two groups were detected by immunoturbidimetric assay at the same time.Results The levels of IL-6,IL-17,IL-23,RF and CRP in serum of the active RA patients were significantly higher than those of normal control group（P〈0.05）.The RF level was positive correlated with IL-17 level.The IL-17 levels of the RA patients were significantly different among different age groups（P〈0.05）.Conclusion IL-6,IL-17,and IL-23 play important roles in the nosogenesis of RA,and IL-17 is expected to become one of the candidate marker for the diagnosis of RA.