1128例幼儿葡萄糖-6-磷酸脱氢酶筛查结果分析

Analysis of G6PD screening results of 1 128 cases of preschool children

目的了解盐田区幼儿园儿童葡萄糖-6-磷酸脱氢酶(G6PD)缺乏症的发生率。方法采用G6PD/6PGD定量比值法测定G6PD活性,筛查盐田区幼儿园1 128例儿童的G6PD缺乏症发生情况。结果 1 128例儿童中,共筛查出G6PD缺乏症患儿56例,发生率为4.96%。其中男性发生率(6.47%)明显高于女性的发生率(3.50%),差异有统计学意义(P<0.05);男性患儿中,重度缺乏的发生率(5.21%)高于中度缺乏的发生率(1.26%),女性患儿中,中度缺乏的发生率(2.28%)高于重度缺乏的发生率(1.22%),差异均具有统计学意义(P<0.05)。结论盐田区属G6PD缺乏症的高发地区,应加强人群的筛查,早期发现和诊断G6PD缺乏症对防治该病引起的溶血具有重要意义。

Objective To investigate the incidence of G6 PD deficiency in preschool children of Yantian District.Methods 1 128 cases of preschool children from kindergarten of Yantian District were screened for G6 PD activity via detecting G6PD/6PDG ratio,and their incidence of G6 PD deficiency was calculated.Results Among the 1128 preschool children,there were 56 cases diagnosed to be G6 PD deficiency,accounting for 4.96%.The incidence rate of the males（6.47%）was higher than the females（3.50%）,and the difference was statistical significance（P〈0.05）.Among the male patients,the incidence rate of severe G6 PD deficiency（5.21%）was higher than moderate G6 PD deficiency（1.26%）,while among the female patients,the incidence rate of moderate G6 PD deficiency（2.28%）was higher than severe G6 PD deficiency（1.22%）,and the differences were statistical significance（P〈0.05）.Conclusion Yantian District is a high-risk area of G6 PD deficiency.In order to early detect and diagnose G6 PD deficiency,the work of G6 PD screening should be strengthened,which is important for the prevention of hematolysis induced by G6 PD deficiency.