银屑病患者血清去氢表雄酮和硫酸去氢表雄酮水平的测定及临床意义

Detection and clinical significance of DHEA and DHEAS in serum from patients with psoriasis vulgaris

目的探讨银屑病患者血清去氢表雄酮(DHEA)和硫酸去氢表雄酮(DHEA-S)水平的临床意义。方法检测银屑病患者(观察组)和健康人群(健康对照组)血清DHEA及DHEA-S水平,并分析其临床意义。结果银屑病患者血清DHEA及DHEA-S水平明显低于健康对照组,差异具有统计学意义(P<0.05)。银屑病患者血清DHEA及DHEA-S水平与病程具有负相关性,病程越长血清DHEA及DHEA-S水平越低(P<0.05)。结论DHEA及DHEA-S与银屑病的发病机制有关。

Objective To explore the clinical significance of dehydroepiandrosterone（DHEA）and dehydroepiandrosterone sulfate（DHEAS）in serum of patients with psoriasis vulgaris.Methods The serum DHEA/DHEA-S levels of 154 psoriasis vulgaris patients and 154 controls were detected,and their situation and clinical features were recorded and analyzed.Results Serum DHEA/DHEA-S in psoriasis vulgaris patients were obviously lower than that in controls,and the differences were statistically significant（P〈0.05）.The serum levels of DHEA and DHEA-S were both negatively correlated with course of psoriasis vulgaris（P〈0.05）.The longer disease course was,the lower serum levels of DHEA and DHEA-S were.Conclusion Serum DHEA and DHEA-S are related to the pathogenesis of psoriasis vulgaris.