摘要
目的探讨银屑病患者血清去氢表雄酮(DHEA)和硫酸去氢表雄酮(DHEA-S)水平的临床意义。方法检测银屑病患者(观察组)和健康人群(健康对照组)血清DHEA及DHEA-S水平,并分析其临床意义。结果银屑病患者血清DHEA及DHEA-S水平明显低于健康对照组,差异具有统计学意义(P<0.05)。银屑病患者血清DHEA及DHEA-S水平与病程具有负相关性,病程越长血清DHEA及DHEA-S水平越低(P<0.05)。结论DHEA及DHEA-S与银屑病的发病机制有关。
Objective To explore the clinical significance of dehydroepiandrosterone(DHEA)and dehydroepiandrosterone sulfate(DHEAS)in serum of patients with psoriasis vulgaris.Methods The serum DHEA/DHEA-S levels of 154 psoriasis vulgaris patients and 154 controls were detected,and their situation and clinical features were recorded and analyzed.Results Serum DHEA/DHEA-S in psoriasis vulgaris patients were obviously lower than that in controls,and the differences were statistically significant(P〈0.05).The serum levels of DHEA and DHEA-S were both negatively correlated with course of psoriasis vulgaris(P〈0.05).The longer disease course was,the lower serum levels of DHEA and DHEA-S were.Conclusion Serum DHEA and DHEA-S are related to the pathogenesis of psoriasis vulgaris.
出处
《检验医学与临床》
CAS
2015年第7期919-920,共2页
Laboratory Medicine and Clinic
基金
广东省深圳市宝安区2014年度科技计划项目(20142477)
关键词
银屑病
去氢表雄酮
硫酸去氢表雄酮
psoriasis
dehydroepiandrosterone
dehydroepiandrosterone sulfate