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MiRNA-138靶向相关蛋白H2AX在肿瘤诊治中的应用价值 被引量：1

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摘要 众所周知,微小RNA（miRNA）通过与mRNA特异性结合而抑制其翻译、降解等过程来控制细胞增殖、分化、应激和凋亡,许多编码miRNA的基因位置与癌症发生变异位置重叠,在癌症发生、发展中起重要作用。应用基因芯片筛选后发现,miRNA-138在宫颈鳞癌细胞中表达差异较为显著,且在新疆维吾尔族宫颈鳞癌组织中表达下调,
作者 张光英 程静新
机构地区 新疆医科大学附属肿瘤医院妇外三科
出处 《检验医学与临床》 CAS 2015年第7期994-996,999,共4页 Laboratory Medicine and Clinic
基金 国家自然科学基金资助项目(81360380)
关键词 H2AX 微小RNA 肿瘤 诊断 治疗敏感性
分类号 R730.4 [医药卫生—肿瘤]
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参考文献36

  • 1苏伟,程静新.microRNA在宫颈癌诊治方面的应用与前景[J].肿瘤基础与临床,2014,27(1):75-78. 被引量：2
  • 2Wang Y, Huang JW, Li M, et al. MicroRNA-138 modu- lates DNA damage response by repressinghistone H2AX expression[J]. Mol Cancer Res, 2011,9 (8) : 1100-1111.
  • 3Wyrick JJ, Parra MA. The role of histone H2A and H2B post-translational modifications in transcription: a genomic perspective[J]. Biochim Biophys Acta,2009,1789(1) :37-44.
  • 4Dickey JS,Redon CE, Nakamura AJ, et al. H2AX: func tional roles and potential applications[J]. Chromosoma, 2009,118(6) : 683-692.
  • 5Olive PL. Detection of DNA damage in individual cells by analysis of histone H2AX phosphorylation[J]. Methods Cell Biol, 2004,75 : 355-373.
  • 6Bourton EC, Plowman PN, Smith D, et al. Prolonged ex- pression of the 7-H2AX DNA repair biomarker correlates with excess acute and chronic toxicity from radiotherapy treatment[J]. Int J Cancer, 2011,129 (12) : 2928-2934.
  • 7Yuan J, Adamski R, Chen J. Focus on histone variant H2AXto be or not to be[J]. FEBS Lett,2010,584(17) : 3717-3724.
  • 8Takahashi A, Mori E, Ohnishi T. The foci of DNA double strand break-recognition proteins localize with rH2AX af- ter heat treatment[J]. J Radiat Res,2010,51(1):91-95.
  • 9Faucher D, Wellinger RJ. Methylated H3K4, a transcrip- tion-associated histone modification, is involved in the DNA damage response pathway[J]. PLoS Genet, 2010,6 (8) :1001082.
  • 10Kinders RJ, Hollingshead M, Lawrence S, et al. Develop- ment of a validated immunofluorescence assay for 7H2AX as a pharmacodynamic marker of topoisomerase I inhibi- tor aetivity [J]. Clin Cancer Res, 2010, 16 (22): 5447- 5457.

二级参考文献61

  • 1徐锋,高建平,程文.MicroRNA与肿瘤[J].东南国防医药,2008,10(6):436-438. 被引量：6
  • 2Herbert J, Coffin J. Reducing patient risk for human papillomavir- us infection and cervical cancer. J Am Osteopath Assoc, 2008, 108(2) : 65-70.
  • 3Dtirst M, Gissmann L, Ikenberg H, et al. A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy sam- ples from different geographic regions. Proc Natl Acad Sci USA, 1983, 80(12) : 3812-3815.
  • 4Boshart M, Gissmann L, Ikenberg H, et al. A new type of papil- lomavirus DNA, its presence in genital cancer biopsies and in cell lines derived from cervical cancer. EMBO J, 1984, 3(5) : 1151- 1157.
  • 5Nam EJ, Kim JW, Hong JW, et al. Expression of the p16 and Ki- 67 in relation to the grade of cervical intraepithelial neoplasia anti high-risk human papillomavirus irffection. J Gynecol Oncol, 2008, 19(3) : 162-168.
  • 6Harris SL, Thorne LB, Seaman WT, et al. Association of p16 (INK4a) overexpression with improved outcomes in young pa- tients with squamous cell cancers of the oral tongue. Head Neck. 2011, 33(11) : 1622-1627.
  • 7He G, Chen L, Ye Y, et al. Piwil2 expressed in various stages of cervical neoplasia is a potential complementary marker for p16. Am J Transl Res, 2010, 2(2) : 156-169.
  • 8Chaurushiya MS, Weitzman MD. Viral manipulation of DNA re- pair and cell cycle checkpoints. DNA Repair ( Amst ) , 2009, 8(9) : 1166-1176.
  • 9Bonner WM, Redon CE, Dickey JS, et al. GammaH2AX and cancer. Nat Rev Cancer, 2008, 8(12) : 957-967.
  • 10Ili CG,Brebi P,López J. Genotyping of human papillomavirus in cervical intraepithelial neoplasia in a high-risk population[J].Journal of Medical Virology,2011,(05):833-837.

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检验医学与临床
2015年 第7期

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