健脾化湿通下方经鼻肠管灌注治疗对恶性小肠梗阻患者生存质量及免疫指标的影响

Influence of “Jianpi Huashi Tongxia Formula”Primed by Nasointestinal Tube on Quality of Life and Immune Indexes in Patients with Malignant Intestinal Obstruction

目的:观察健脾化湿通下方经鼻肠管灌注治疗对恶性小肠梗阻患者生存质量及机体免疫功能的影响。方法:将60例恶性小肠梗阻患者随机分为对照组和治疗组,每组30例。所有患者均给予西医常规治疗,治疗组患者在此基础上给予健脾化湿通下方经鼻肠管灌注治疗,治疗周期为28 d。采用Karnofsky功能状态(KPS)评分评估患者的生存质量,比较两组患者体质量的变化,检测并比较两组患者的血清C反应蛋白(CRP)及T淋巴细胞亚群CD3+、CD4+、CD8+、CD4+/CD8+水平。结果:治疗后,治疗组患者的生存质量改善情况优于对照组(P<0.05),且治疗组患者的体重高于对照组(P<0.05)。治疗后,两组患者的血清CRP及CD8+水平均显著降低(P<0.05),且治疗组患者的CRP及CD8+水平低于对照组(P<0.05);治疗组患者的CD3+水平显著升高(P<0.05),对照组患者的CD3+水平显著降低(P<0.05),治疗组患者的CD3+水平显著高于对照组(P<0.05);治疗组患者的CD4+水平显著升高(P<0.05),且显著高于对照组(P<0.05);两组患者的CD4+/CD8+均显著升高(P<0.05),且治疗组患者的CD4+/CD8+高于对照组(P<0.05)。结论:健脾化湿通下方经鼻肠管灌注治疗能够明显改善恶性小肠梗阻患者的生存质量,提高患者的免疫功能。

Objective： To observe the influence of ＂Jianpi Huashi Tongxia Formula＂ primed by nasointestinal tube on the quality of life and the immune function in treating patients with malignant intestinal obstruction. Methods ： Sixty patients of malignant intestinal obstruction were randomly divided into control group and treatment group, with 30 cases in each group. All the patients were treated by conventional western medical therapy, and the patients in the treatment group were added with ＂Jianpi Huashi Tongxia Formula＂ primed through nasointestinal tube, with a course of 28 days. The quality of life was evaluated by KPS scores, the body weight was compared between the two groups, and the immune indexes including C reactive protein （CRP）, CD3 ＋, CD4 ＋, CD8 ＋ and CD4＋/CD8 ＋ were detected. Results： After treatment, the improvement of life quality of patients in the treatment group was better than that in the control group （ P 〈 0.05 ）, and the body weight of the treatment group was higher than that of the control group （ P 〈0.05 ）. After treatment, the levels of serum CRP and CD8 ＋ of both groups were markedly decreased （ P 〈 0.05 ）, and the levels of serum CRP and CD8 ＋of the treatment group were lower than those of the control group （ P 〈 0.05 ） ; the level of CD3 ＋ of treatment group was increased （ P 〈 0.05 ）, the level of CD3 ＋ of control group was decreased （ P 〈0.05 ）, and the level of CD3 ＋ of treatment group was higher than that of the control group （ P 〈 0.05 ） ; the level of CD4 ＋ of the treatment group was increased （ P 〈 0.05 ） and was higher than that of the control group （ P 〈 0.05 ） ; the ratio of CD4 ＋/CD8 ＋ of both groups was increased （ P 〈 0.05 ）, and the ratio of CD4 ＊/CD8 ＋ of the treatment group was higher than that of the control group （ P 〈 0.05 ）. Conclusion ： ＂Jianpi Huashi Tongxia Formula＂ primed by nasointestinal tube can significantly improve the quality of life and enhance the immune function for patients with malignant intestinal obstruction.