摘要
目的:探讨血清降钙素原(PCT)和超敏C反应蛋白(hs-CRP)检测在慢性阻塞性肺疾病急性加重期(AECOPD)患者加重病因判定中的临床价值。方法:选择慢性阻塞性肺疾病(COPD)稳定期患者50例(稳定组)和加重期患者50例(加重组),测定血清PCT和hs-CRP。结果:加重组患者血清PCT和hs-CRP水平均高于稳定组,差异有统计学意义(P<0.05)。感染组患者血清PCT和hsCRP水平均高于非感染组,差异有统计学意义(P<0.05)。判定AECOPD患者是否由感染因素加重,血清PCT的敏感性87.50%、特异性72.22%、准确性82.00%,血清hs-CRP的敏感性90.63%、特异性66.66%、准确性82.00%,二者联合的敏感性96.88%、特异性94.44%、准确性96.00%。结论:COPD患者急性加重期血清PCT和hs-CRP水平升高,因感染原因加重者血清PCT和hs-CRP水平更高,血清PCT联合hs-CRP有利于判定COPD加重的原因。
Objective:To investigate the clinical value of serum procalcitonin ( PCT) and hypersensi-tive C reaction protein ( hs-CRP ) assays in judgment of causes of exacerbation in acute exacerbation phase of chronic obstructive pulmonary disease (AECOPD) patients.Method:50 patients in stable phase of COPD (stable group) and another 50 patients in exacerbation phase of COPD (exacerbation group) were selected, and the serum PCT and hs-CRP contents were assayed .Result:The serum PCT and hs-CRP levels in the patients of the exacerbation group were both higher than those of the stable phase , and the differences were statistically significant ( P&lt;0.05) .The serum PCT and hs-CRP levels in the patients of infection group were both higher than those of infection-free group, and the differences were statistically significant (P〈0.05). When judgment of whether the AECOPD patients were exacerbated because of infection , the sensitivity, spe-cificity and accuracy of serum PCT level were 87.50%, 72.22%, and 82.00%, respectively;those of serum hs-CRP level were 90.63%, 66.66%, and 82.00%, respectively;and those of the two in combination were 96.88%, 94.44%, and 96.00%, respectively.Conclusion:In acute exacerbation phase of COPD , the serum PCT and hs-CRP levels are both increased , and in the patients who were exacerbated because of infection , the serum PCT and hs-CRP levels were even higher .Serum PCT assay combined with serum hs-CRP assay is conducive to judgment of causes of exacerbation of COPD .
出处
《河北医学》
CAS
2015年第6期923-925,共3页
Hebei Medicine
基金
四川省资阳市科技局立项课题
(编号:20130015)
关键词
慢性阻塞性肺疾病
急性加重期
降钙素原
超敏C反应蛋白
Chronic obstructive pulmonary disease
Acute exacerbation phase
Procalcitonin
Hypersensitive C reaction protein