150例肝外胆管癌的临床病理与预后分析

150 Cases Clinical Pathology and Prognosis of Extrahepatic Bile Duct Carcinoma

目的:探讨肝外胆管癌的临床病理特点及预后分析。方法:选取2007年1月至2013年1月收治的150例肝外胆管癌患者,给予手术治疗,对患者术后的临床病理特点进行回顾性统计,选择Kaplan-Meier方法分析病理与预后的联系。结果:经过分析后得知,肝外胆管癌患者的1年生存率70.6%、2年生存率18.0%、3年生存率4.0%,平均生存时间18.5月。姑息性手术与根治性手术的生存率存在明显差异(P<0.05)。另外,肝管周围组织浸润阴性者预后效果明显优于阳性者(P<0.05)。肿瘤分化程度越好,患者预后效果越好。结论:针对肝外胆管癌患者,其术后预后因素主要包含肿瘤分化程度、肿瘤浸润和根治性手术,临床治疗时应考虑这些预后因素。

Objective：To study the clinical and pathological characteristics and prognosis of extrahepat-ic bile duct carcinoma .Method： 150 cases of extrahepatic bile duct carcinoma in our hospital from Jan . 2007 Jan .to 2013 underment operation treatment , clinical and pathological features of patients after surgery were analyzed , Select the Kaplan-Meier method was selected to analyze the contact of pathology and progno-sis.Result：It showed that , 1 year survival rate of extrahepatic bile duct cancer patients was 70.6%, 2 years survival rate was 18%, 3 years survival rate was 4%, the average survival time was 18.5 months.Palliative operation had obvious difference with radical operation survival rate （P〈0.05）.In addition, prognostic effect of the surrounding tissue invasion negative of hepatic duct was better than positive （ P〈0.05） .The better de-gree of tumor differentiation , the better prognosis .Conclusion：For patients with extrahepatic bile duct carci-noma, the main prognostic factors is tumor differentiation , tumor invasion and radical radical surgery , these factors of prognosis should be considered for clinical treatment.