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MSCs移植治疗对缺血性心肌病患者左室收缩功能影响的Meta分析 被引量：2

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摘要 目的系统评价骨髓源性间充质干细胞(MSCs)移植对缺血性心肌病(IHD)左室收缩功能的影响。方法以"缺血性心肌病"、"骨髓间充质干细胞"为关键词检索2014年4月前美国国立医学图书馆生物医信息检索系统(Pub Med)、美国生物科学数据库(Biosis Previews)、考克兰图书馆(The Cochrane Library)、中国知网、万方数据库、维普中文科技期刊全文数据库等数据库内MSCs移植对IHD左室收缩功能的随机对照试验,对纳入文献进行质量评价,采用Revman 5.2软件对纳入研究进行Meta分析。结果最终纳入文献5篇,共236例患者,其中治疗组124例,均接受MSCs移植,112例对照组接受安慰剂或标准治疗。Meta分析结果显示,与对照组比较,MSCs治疗可明显增加LVEF、降低左室舒张未期内径(LVEDV)和左室收缩末期内径(LVESV)。两组间MACEs差异无统计学意义。结论 MSCs移植可改善IHD左室收缩功能,且临床主要不良事件发生较少。
作者 陈丽媛 符春晖
机构地区 钦州市第二人民医院
出处 《山东医药》 CAS 北大核心 2015年第14期56-58,共3页 Shandong Medical Journal
关键词 骨髓间充质干细胞 缺血性心肌病 左室收缩功能
分类号 R541.6 [医药卫生—心血管疾病]
  • 相关文献

参考文献17

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共引文献1

同被引文献50

  • 1徐瑾,王彬尧,陈颖敏,何奔.经静脉移植骨髓间充质干细胞向扩张性心肌病大鼠心肌趋化的研究[J].心脏杂志,2007,19(3):262-265. 被引量：3
  • 2李杨,陈沅,田杰,邱俊,朱静,张小飞.心肌病大鼠骨髓间充质干细胞移植后差异表达基因cDNA文库的构建[J].中国组织工程研究与临床康复,2007,11(37):7365-7368. 被引量：2
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引证文献2

二级引证文献7

山东医药
2015年 第14期

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