天麻钩藤颗粒对原发性高血压患者血管功能的影响

Effect of “Tianma Gouteng Granules” on vascular function in patients with primary hypertension

目的观察天麻钩藤颗粒治疗原发性高血压的临床疗效及其对血管功能的影响。方法将107例原发性高血压患者随机分为对照组(53例)和观察组(54例);对照组口服硝苯地平控释片,观察组口服硝苯地平控释片和天麻钩藤颗粒,疗程3个月;观察两组临床疗效、血管扩张能力(FMD)和颈动脉内膜中层厚度(CIMT)、SOD、ET和MDA含量变化。结果 1观察组总有效率为94.4%,对照组为81.1%;观察组临床疗效优于对照组(P<0.05)。2治疗后两组FMD升高(P<0.05),且观察组高于对照组(P<0.05);两组IMT降低(P<0.05),且观察组低于对照组(P<0.05)。3治疗后,两组SOD升高(P<0.05),且观察组高于对照组(P<0.05);两组ET和MDA降低(P<0.05),且观察组低于对照组(P<0.05)。结论天麻钩藤颗粒治疗原发性高血压可提高临床疗效,改善血管功能和增加抗氧化活性。

Objective To observe the clinical efficacy of ＂Tianma Gouteng Granules ＂ and its effect on vascular function in treating patients with primary hypertension. Methods One hundred and seven cases with primary hypertension were randomized into control group（ n = 53） and observation group（ n = 54）.The control group was treated with Nifedipine controlled-release Tablets orally,and observation group was treated with＂Tianma Gouteng Granules＂additionally,with the course of 3 months. The clinical efficacy and contents of FMD,CIMT,SOD,ET and MDA were observed. Results 1 The total effective rate was94. 4% in the observation group and 81. 1% in the control group,the clinical efficacy of the treatment group was superior to that of the control group（ P 〈 0. 05）.2 After treatment,the FMD was increased in both two groups（ P 〈 0. 05）,the observation group was higher than that of the controls（ P 〈 0. 05）; but IMT was decreased in both groups（ P 〈 0. 05）,and the observation group was lower than that of the controls（ P 〈 0. 05）. 3After treatment,the SOD was increased in both two groups（ P 〈 0. 05）,and observation group was higher than the controls（ P 〈 0. 05）; levels of ET and MDA in both groups were decreased（ P 〈 0. 05）,and the observation group was lower than that of the control group（ P 〈 0. 05）. Conclusion ＂Tianma Gouteng Granules＂is effective to improve the clinical efficacy,improve vascular function and antioxidant activity in patients with primary hypertension.