复发性子宫苗勒源腺纤维瘤临床病理分析

Clinicopathological analysis of recurrent uterine Mullerian adenofibroma

目的探讨复发性子宫苗勒源腺纤维瘤临床病理特征。方法选取2003年2月至2014年2月该院收治的复发性子宫苗勒源腺纤维瘤患者8例,分析其临床数据,总结子宫苗勒源腺纤维瘤的病理特点。结果 8例复发性子宫苗勒源腺纤维瘤患者可在宫颈外或者宫腔内见分叶状赘生物,由良性上皮和间叶组织形成。免疫组化显示,8例患者均表达雌激素受体(ER),部分患者表达孕激素受体(PR)、平滑肌肌动蛋白(SMA)、CD10和p53,而Ki-67(+)均值平均为8%。结论复发性子宫苗勒源腺纤维瘤临床病理无特异性变化,与腺肉瘤鉴别诊断困难,仅CD10和Ki-67可能有助于诊断。

Objective To analyze and summarize the clinicopathological features of recurrent uterine Mullein adenofibroma . Methods 8 cases of recurrent uterine Mullein adenofibroma in our hospital from February 2003 to February 2014 were selected and analyzed on the clinical data for summarizing its clinicopathological features .Results In 8 cases of recurrent uterine M ullerian ade‐nofibroma ,the lobulated neoplasm could be found on outside of the cervix or inside of the uterus ,which was formed by the benign epithelial and mesenchymal tissue .Immunohistochemistry showed that the estrogen receptor （ER） was expressed in 8 cases ,some cases expressed progesterone receptor（PR） ,smooth muscle actin（SMA） ,CD10 and p53 ,and the mean average value of Ki‐67 （＋ ） was 8% .Conclusion Recurrent uterine Mullerian adenofibroma has no specific clinicopathological changes ,its differential diagnosis with sarcoma is difficult .Only CD10 and Ki‐67 may be conducive to diagnosis .