重庆市健康体检人群中乙型肝炎感染的现状及模式分析

Analysis of infection status and patterns of hepatitis B among population of health examination in Chongqing

目的了解重庆市健康体检人群中乙型肝炎（乙肝）病毒（HBV）的感染现状,并对乙肝结果模式进行分析。方法回顾性分析2013年6~12月在第三军医大学大坪医院健康体检的30 170例血清中HBV表面抗原（HBsAg）、HBV表面抗体（HBsAb）、HBVe抗原（HBeAg）、HBVe抗体（HBeAb）和HBV核心抗体（HBcAb）结果。结果该市0~96岁健康体检人群中HBsAg的阳性率为8.02%（2 419/30 170）,不同年龄组和不同性别的阳性率比较,差异有统计学意义（χ2=188.045、67.813,P〈0.01）;HBV感染率为28.64%（8 641/30 170）,不同年龄组和不同性别的感染率比较,差异均有统计学意义（χ2=202.347、36.171,P〈0.01）。30 170例体检者乙肝5项（HBsAg1、HBsAb2、HBeAg3、HBeAb4、HBcAb5）检测结果归纳为14种模式。全为阴性、单独HBsAb阳性作为健康人群常见的两种模式,其百分比分别为25.76%（7 772/30 170）和45.60%（13 757/30 170）;作为HBV感染者的常见模式＂145＂阳性、＂135＂阳性及＂15＂阳性所占百分比分别为6.18%（1 863/30 170）、0.59%（177/30 170）和1.21%（366/30 170）。结论该市健康体检人群中HBsAg阳性率和HBV感染率接近或低于全国平均水平;通过对不同组合模式的分析,可反映HBV感染的不同情况,对疾病的诊断和预后有指导意义。

[Abstract ] Objective To understand the infection status of hepatitis B among population of health examination in Chongqing ,and to analyze the modes of hepatitis B outcomes .Methods The 30170 cases of serological results of hepatitis B （HB‐sAg① ,HBsAb② ,HBeAg③ ,HBeAb④ and HBcAb⑤ ） among the individuals of health examination in our hospital from June to December 2013 were performed the retrospective analysis .Results The positive rate of HBsAg among the population of health ex‐amination aged 0-96 years old in Chongqing was 8 .02% （2 419/30 170） ,and the differences in the positive rates among different age groups and between different genders had statistical significance （χ2 =188 .045 ,67 .813 ,P〈0 .01） .The infection rate of HBV was 28 .64% （8 641/30 170） ,and the difference in the infection rates among different age groups and between different genders also had statistical significance（χ2 =202 .347 ,36 .171 ,P〈0 .01） .30 170 cases of hepatitis B detection results of 5 indexes were conclu‐ded into 14 kinds of modes .As the two common modes of healthy population ,all negative and single HBsAb positive ,their percenta‐ges were 25 .76% （7 772/30 170）and 45 .60% （13 757/30 170）respectively .As the common modes of HBV infection ,“① ④ ⑤”posi‐tive ,“① ③ ⑤” positive and“① ⑤” positive ,their percentages were 6 .18% （1 863/30 170） ,0 .59% （177/30 170） and 1 .21% （366/30 170） respectively .Conclusion The positive rate of HBsAg and the infection rate of HBV among population of health examina‐tion in Chongqing are close to or lower than the national average levels .Analyzing the different combination modes can reflect the different situation of HBV infection and has the guidance significance for the diagnosis and prognosis of the disease .