食物不耐受特异性IgG抗体与肠易激综合征关系的临床研究

Clinical study of relationship between specific IgG antibody of food intolerance and irritable bowel syndrome

目的探讨食物不耐受特异性Ig G抗体与肠易激综合征(IBS)的关系。方法对128例IBS患者和80例健康体检者,应用酶联免疫吸附法半定量检测血清中14种食物不耐受特异性lg G抗体水平并分为0、+1、+2和+3级;根据检测结果剔除相应食物治疗8周,采用调查表评分系统对IBS患者的症状进行评分以评价疗效。结果 128例IBS患者中,至少有1种食物不耐受特异性Ig G抗体阳性112例,阳性率为87.5%,明显高于对照组的9.3%(P<0.05)。IBS患者食物不耐受特异性Ig G阳性率以蟹(84.4%)和虾(75.0%)较高。128例IBS患者中Ig G抗体阳性+2以上的患者82例,经剔除相应食物治疗8周后,临床症状明显改善56例(68.3%),症状有所改善16例(19.5%),无效10例(12.2%),总有效率为87.8%(72/82)。结论根据IBS患者血清中食物不耐受特异性Ig G水平,剔除相应食物,能有效地改善IBS的临床症状。

Objective To explore the relationship between specific IgG antibody of food intolerance and irritable bowel syndrome （ IBS） .Methods The levels of 14 serum specific lgG antibodies of food intolerance were detected by semi-quantitative enzyme-linked immunosorbent assay among 128 patients with IBS and 80 healthy controls,which were classified into grade 0,grade ＋1,grade ＋2 and grade ＋3.The patients were treated for 8 weeks following eliminating the corresponding foods according to the result of the detection .And then a questionnaire scoring system was applied to assessing the effects on the patients according to the symptoms of patients with IBS . Results Among 128 patients with IBS,there were 112 with one or more specific lgG antibodies of food intolerance ,with a positive rate of 87.5%which was significantly higher than that（9.3%） of control group（P＆lt;0.05）.The most common intolerant foods were crab（the positive rate of 84.4%）and shrimp （the positive rate of 75.0%） in patients with IBS.Eighty-two of 128 IBS patients,with positive IgG antibody of grade＋2 or higher,received a diet therapy of eliminating the corresponding food for 8 weeks.Of these 82 cases,56（68.3%）improved significantly, 16（19.5%） improved,10（12.2%） ineffective,the overall effective rate was 87.8%（72/82）.Conclusion The measurement of eliminating the corresponding food according to the level of specific IgG antibody of food intolerance might contribute to improving the clinical symptoms of IBS .