腹腔镜下全子宫切除术加输卵管切除术对围绝经期妇女的影响

Influence of laparoscopic hysterectomy and salpingectomy on perimenopausal women

目的探讨围绝经期妇女行腹腔镜下全子宫和双侧输卵管切除术对卵巢功能、围绝经期症状的影响。方法将80例子宫良性病患者随机分为两组,观察组40例行腹腔镜下全子宫全切除术加双侧输卵管切除术,对照组40例仅行全子宫切除术。两组均随访12个月,观察两组术前及术后1、3、6、12个月血雌二醇(E2)、卵泡刺激素(FSH)、黄体生成素(LH)水平及围绝经期症状发生情况。结果两组患者各时间点E2、FSH、LH水平比较,差异均无统计学意义(P>0.05);但两组E2水平随着时间延长而降低(P<0.05);FSH、LH水平随着时间延长而升高(P<0.05)。两组患者术后1、3、6、12个月围绝经期症状发生率比较,差异均无统计学意义(P>0.05)。结论围绝经期子宫良性病患者行腹腔镜下全子宫切除术加双侧输卵管切除术或单纯施行全子宫切除术对患者的卵巢功能和围绝经期症状的影响相似。

Objective To investigate the influence of laparoscopic hysterectomy and bilateral salpingectomy on ovarian function and menopausal symptoms of perimenopausal women .Methods Eighty patients with benign uterine diseases were randomly divided into two groups.Forty cases in the observation group underwent laparoscopic hysterectomy and bilateral salpingectomy ,while 40 cases in the control group underwent hysterectomy alone .The two groups were followed up for 12 months.The observation on the levels of serum estradiol （E2）,follicule-stimulating hormone（FSH） and luteinizing hormone（LH） before and 1,3,6,12 months after operation as well as the postoperative incidences of perimenopausal symptoms was performed in two groups.Results There were no significant differences in the levels of E2,FSH and LH at each time point between two groups（P＆gt;0.05）.The level of E2 decreased with the increasing time in two groups（P＆lt;0.05）,while the levels of FSH,LH increased with the increasing time（P＆lt;0.05）.There were no significant differences in the incidences of perimenopausal symptoms 1,3,6,12 months after operation between two groups（P＆gt;0.05）.Conclusion Laparoscopic hysterectomy plus bilateral salpingectomy has similar influence on the ovarian function and perimenopausal symptoms of postmenopausal women with benign uterine diseases compared with hysterectomy alone.