高频超声探测甲状腺结节钙化模式与甲状腺癌的相关性

Calcification modes of thyroid nodules by high-frequency ultrasonography and its correlation with thyroid carcinoma

目的探讨甲状腺结节内不同模式钙化与甲状腺癌的关系。方法收集本院4年间行甲状腺结节手术及穿刺活检的193例患者的资料,对比甲状腺结节术前彩色多普勒超声诊断与术后病理诊断的关系,重点观察甲状腺内有无钙化,探讨微沙粒样钙化、粗大钙化、孤立钙化、弧形钙化与甲状腺癌的关系。结果 193例患者中,存在钙化的89例,其中54例术后病理证实为甲状腺癌,依据钙化灶模式分型,伴微沙粒样钙化的结节39例,伴粗钙化的结节8例,弧形钙化的结节6例,周边无甲状腺结节的孤立钙化灶1例。结论是否钙化对鉴别甲状腺结节的良、恶性具有临床意义,其中沙粒样钙化预测甲状腺癌的特异性极高。

Objective To investigate the relationship between different modes of calcification in thyroid nodules and thyroid carcinoma. Methods Medical data of 193 patients,who underwent thyroid nodule surgery and needle biopsy in the last 4 years,were collected for the study. The mode of thyroid nodules revealed by color Doppler ultrasonography before surgery was compared with the change detected by surgical pathologic diagnosis. The focus of the observation was to see if there was calcification in the thyroid,and to investigate the relationship between various modes of the calcification（ e. g. fine granule-like calcification,coarse calcification,isolated calcification and arc calcification） and thyroid carcinoma. Results In the 193 cases,89 were revealed to have calcification,of which 54 were proved to be thyroid carcinoma by surgical pathologic detection. In accordance with calcification modes,there were 39 cases with fine granule-like calcification nodule,8 cases with coarse calcification nodule,6 cases with arc calcification nodule,and one case with isolated calcification focus,but without peripheral thyroid nodule. Conclusion Thyroid calcification was an important indicator for the differentiation between the benign and malignant tumors,and fine granule-like thyroid calcification was highly specific in the prediction of thyroid carcinoma.