高龄男性腔隙性脑梗死的严重程度与血清胆红素水平的相关性

Association between lacunar infarction and serum bilirubin level in advance-aged male patients

目的探讨高龄（≥80岁）男性患者腔隙性脑梗死（lacunar infarction,LI）与血清胆红素水平的相关性。方法选择经头颅MRI证实的老年男性LI患者98例,根据病灶数目分为LI单发组36例和LI多发组62例。分析血清总胆红素、直接胆红素和间接胆红素等临床资料。再根据总胆红素水平分为高水平患者35例（10.6~21.0μmol/L）和低水平患者63例（0~10.5μmol/L）,评价LI的严重程度。结果 LI单发组与LI多发组总胆红素、直接胆红素和间接胆红素比较,差异无统计学意义（P〉0.05）,多因素logistic回归分析显示,危险因素与LI的发生无相关性（P〉0.05）。胆红素低水平患者与高水平患者的LI个数比较,差异无统计学意义[（5.3 vs 4.7）个,P〉0.05],校正其他危险因素后,胆红素低水平与高水平LI个数比较,差异无统计学意义（OR=0.97,95%CI：0.90~1.06,P=0.50）。结论高龄男性胆红素水平与LI的严重程度无相关性。

Objective To study the association between lacunar infarction（LI）and serum bilirubin level in advance-aged male patients（≥80years）.Methods Ninety-eight male LI patients were divided into single LI group（n=36）and multiple LI group（n=62）.Their serum levels of total,direct,and indirect bilirubin were analyzed.The patients were further divided into high total bilirubin（10.6-21.0μmol/L）group（n=35）and low total bilirubin（0-10.5μmol/L）group（n=63）.The severity of their LI was assessed.Results No significant difference was found in the serum levels of total,direct,and indirect bilirubin between single and multiple LI groups（P〈0.05）.Multvariate regression analysis showed that the risk factors for LI were not related with its occurrence（P〈0.05）.No significant difference was found in the number of LI lesios between high and low bilirubin groups after adjustment for other risk factors（5.3 vs 4.7,OR=0.97,95%CI：0.90-1.06,P=0.50）.Conclusion The serum bilirubin level is not related with the severity of LI in advance-aged male patients.