前循环进展性脑梗死患者颈动脉硬化分析及血小板CD62p表达

Carotid atherosclerosis and platelet CD62p expression in patients with anterior circulation progressive ischemic stroke

目的分析前循环进展性脑梗死患者颈动脉硬化及血小板活化功能;并探讨颈动脉斑块性质与血小板活化关系。方法选择急性前循环脑梗死患者110例,根据病情分为进展组56例和非进展组54例;另选健康体检者40例为对照组。采用流式细胞仪测定其血小板活化指标CD62p的表达,同时行颈动脉多普勒超声检查。根据颈动脉斑块性质将脑梗死患者分为无斑块27例、稳定斑块43例和不稳定斑块40例,比较CD62p的表达。结果进展组颈动脉斑块以不稳定斑块为主(44.6%);与对照组比较,进展组和非进展组CD62p明显升高[(17.75±2.26)%vs(10.26±1.87)%vs(4.50±1.15)%,P<0.05];与无斑块患者比较,不稳定斑块和稳定斑块患者CD62p明显升高[(15.28±2.12)%vs(9.09±1.70)%vs(5.23±1.28)%,P<0.05]。结论颈动脉斑块不稳定性、血小板活化指标CD62p与脑卒中进展有关;血小板活化指标CD62p表达的高低与斑块性质相关。

Objective To study the association between carotid atherosclerosis and platelet CD62 p expression in patients with anterior circulation progressive ischemic stroke（PIS）.Methods One hundred and ten patients with acute anterior circulation ischemic stroke were divided into PIS group（n=56）and non-PIS group（n=54）.Forty healthy subjects undergoing physical examination served as a control group.Their CD62 p expressions were detected by flow cytowetry.The patients who underwent carotid Doppler ultrasonography were further divided into no plaque group（n=27）,stable plaque group（n=43）,and unstable plaque group（n=40）.Their CD62 p expressions were compared.Results Unstable plaques were mainly found in PIS group,accounting for44.6%.The CD62 p expression level was significantly higher in PIS group and non-PIS group than in control group and in unstable plaque group and stable plaque group than in no plaque group（17.75% ±2.26% vs 10.26% ±1.87%,17.75% ±2.26% vs 4.50% ±1.15%,P〈0.05;15.28%±2.12%vs 9.09%±1.70%,15.28%±2.12% vs 5.23%±1.28%,P〈0.05）.Conclusion Unstable carotid plaques and CD62 p expression level are related with PIS and CD62 p expression level is related with unstable carotid plaques.