北京地区老年男性维生素D营养状态调查及与心血管危险因素相关性初探

Preliminary study on serum 25(OH) D level and its relationship with cardiovascular risk factors in aged males in Beijing

目的了解老年男性维生素D营养状态,并初步探讨25-羟基维生素D[25（OH）D]与心血管危险因素的相关性。方法选取2013年1月~2013年5月在解放军总医院门诊查体的老年男性472名,评估北京地区老年男性血清维生素D水平,并分析25（OH）D水平与血脂、血压、体质量指数（BMI）、全血糖化血红蛋白（Hb A1C）、空腹血糖（FBP）的相关性。结果472名老年男性的血清25（OH）D水平平均为（19.47±11.32）ng/ml,其中严重缺乏、缺乏、不足、充足者所占比例分别为20.97%、39.20%、24.36%、15.47%。25（OH）D与总胆固醇/高密度脂蛋白（TC/HDL-C）、低密度脂蛋白/高密度脂蛋白（LDL-C/HDL-C）水平呈显著负相关,与HDL-C呈显著正相关。25（OH）D水平与收缩压（SBP）呈显著负相关,与舒张压（DBP）未见明显相关性。不同25（OH）D水平组有显著差异,进一步分析不同BMI水平组25（OH）D变化,将研究对象根据BMI水平分为正常组、超重组、肥胖组,结果发现,随BMI上升,25（OH）D水平显著下降。非糖尿病组及糖尿病组25（OH）D与Hb A1C均呈负相关,与FBP无明显相关性。多元逐步回归结果显示,25（OH）D与Hb A1C、HDL-C、SBP均显著相关。结论北京市老年男性维生素D缺乏现象普遍,且维生素D营养状态与多项心血管疾病危险因素均有显著相关性。

Objective To investigate the serum 25（OH） D level in aged males and discussed the relation of 25（OH） D and cardiovascular risk factors. Methods A total of 472 patients between the age of 60 and 99 were selected in Beijing from January to May in 2013. The level of serum 25（OH） D of all patients were examined. All subjects were divided into 4 groups based on the 25（OH） D cuf-off values： 10 ng/ml,10 ~ 20 ng/ml,20 ~ 30 ng/ml,30 ~ 60 ng/ml,which corresponds to four vitamin D status：seriously deficient,deficient,insufficient,and sufficient. We assessed the vitamin D status of elderly men and explored the association between 25（OH）D and cardiovascular risk factors. Results The average serum 25（OH） D level was（19.47 ± 11.32） ng/ml,and the proportion of vitamin D serious deficiency group,deficiency group,insufficiency group and sufficiency group were 20.97%,39.2%,24.36% and15.47% respectively. The level of serum 25（OH） D was inversely associated with TC/HDL- C,LDL- C/HDL-C,and was positively associated with HDL-C. The Level of serum 25（OH） D was inversely associated with SBP,but it had no correlation with DBP.According to BMI level,participants were divided into three groups：normal BMI group,overweight group and obesity group. With the increase of BMI,the 25（OH） D level decreased significantly. In both diabetic and non-diabetic groups,the 25（OH） D level was inversely associated with HbA1C. Multiple regression analysis showed that serum 25（OH） D was significantly associated with HbA1C,HDL-C cholesterol and SBP. Conclusion Vitamin D deficiency is quite prevalent in aged males in Beijing. Vitamin D status is closely related to many cardiovascular risk factors.