摘要
目的了解老年男性维生素D营养状态,并初步探讨25-羟基维生素D[25(OH)D]与心血管危险因素的相关性。方法选取2013年1月~2013年5月在解放军总医院门诊查体的老年男性472名,评估北京地区老年男性血清维生素D水平,并分析25(OH)D水平与血脂、血压、体质量指数(BMI)、全血糖化血红蛋白(Hb A1C)、空腹血糖(FBP)的相关性。结果472名老年男性的血清25(OH)D水平平均为(19.47±11.32)ng/ml,其中严重缺乏、缺乏、不足、充足者所占比例分别为20.97%、39.20%、24.36%、15.47%。25(OH)D与总胆固醇/高密度脂蛋白(TC/HDL-C)、低密度脂蛋白/高密度脂蛋白(LDL-C/HDL-C)水平呈显著负相关,与HDL-C呈显著正相关。25(OH)D水平与收缩压(SBP)呈显著负相关,与舒张压(DBP)未见明显相关性。不同25(OH)D水平组有显著差异,进一步分析不同BMI水平组25(OH)D变化,将研究对象根据BMI水平分为正常组、超重组、肥胖组,结果发现,随BMI上升,25(OH)D水平显著下降。非糖尿病组及糖尿病组25(OH)D与Hb A1C均呈负相关,与FBP无明显相关性。多元逐步回归结果显示,25(OH)D与Hb A1C、HDL-C、SBP均显著相关。结论北京市老年男性维生素D缺乏现象普遍,且维生素D营养状态与多项心血管疾病危险因素均有显著相关性。
Objective To investigate the serum 25(OH) D level in aged males and discussed the relation of 25(OH) D and cardiovascular risk factors. Methods A total of 472 patients between the age of 60 and 99 were selected in Beijing from January to May in 2013. The level of serum 25(OH) D of all patients were examined. All subjects were divided into 4 groups based on the 25(OH) D cuf-off values: 10 ng/ml,10 ~ 20 ng/ml,20 ~ 30 ng/ml,30 ~ 60 ng/ml,which corresponds to four vitamin D status:seriously deficient,deficient,insufficient,and sufficient. We assessed the vitamin D status of elderly men and explored the association between 25(OH)D and cardiovascular risk factors. Results The average serum 25(OH) D level was(19.47 ± 11.32) ng/ml,and the proportion of vitamin D serious deficiency group,deficiency group,insufficiency group and sufficiency group were 20.97%,39.2%,24.36% and15.47% respectively. The level of serum 25(OH) D was inversely associated with TC/HDL- C,LDL- C/HDL-C,and was positively associated with HDL-C. The Level of serum 25(OH) D was inversely associated with SBP,but it had no correlation with DBP.According to BMI level,participants were divided into three groups:normal BMI group,overweight group and obesity group. With the increase of BMI,the 25(OH) D level decreased significantly. In both diabetic and non-diabetic groups,the 25(OH) D level was inversely associated with HbA1C. Multiple regression analysis showed that serum 25(OH) D was significantly associated with HbA1C,HDL-C cholesterol and SBP. Conclusion Vitamin D deficiency is quite prevalent in aged males in Beijing. Vitamin D status is closely related to many cardiovascular risk factors.
出处
《中华保健医学杂志》
2015年第1期10-13,共4页
Chinese Journal of Health Care and Medicine
基金
军队保健专项科研课题(12BJZ42)
解放军总医院临床科研扶持基金(2014FC-TSYS-1008)
解放军总医院百病妙决(MJ 201440)