高龄男性脑白质损伤的严重度与血清胆红素水平的相关性

The relationship between white matter lesions and serum bilirubin level in elderly male patients

目的探讨老年（≥80岁）男性脑白质损伤（white matter lesins,WML）与血清胆红素水平的相关性。方法严格按入组及排除标准,选择经头颅MRI证实的老年男性WML患者92例,依据年龄相关的脑白质视觉评定法（0-30分）对WML严重程度进行评估后,将患者分为WML轻度（1-4分）组和WMH中-重度（5-30分）组两组。着重分析血清总胆红素（TBIL）、直接胆红素（DBIL）、间接胆红素（IBIL）等临床资料,再根据总胆红素水平将患者分为高水平组（10.6-21.0μmol/L）和低水平组（0-10.5μmol/L）,以评价两组WML的严重程度。结果 WML轻度组和WMH中-重度组患者的TBIL、DBIL、IBIL比较,差异均无统计学意义（P〉0.05）,胆红素高水平组和低水平组的WML评分差异也无统计学意义（P〉0.05）。结论老年男性腔隙性脑梗死患者血清胆红素水平与WML不相关。

Objective To investigate the association of white matter lesions（WML） with serum bilirubin level in elderly male patients. Methods A total of 92 cases of male white matter lesions patients were selected. White matter lesions were detected with MRI. According to Age-Related White Matter Changes scale（0 - 30 score） for WML severity assessment,patients were divided into mild group（1 - 4 score） and moderate -severe group（5 - 30 score）,compare the serum bilirubin level and other clinical information between the two groups. All the patients according to serum bilirubin level divided into high（10.6 - 21.0 μmol/L） and low（0 -10.5 μmol/L） groups,compare WML scores and other clinical information between the two groups. The odds ratios for WML were calculated using multivariate logistic regression across serum total bilirubin. Results serum bilirubin level and other clinical information were compared between the two groups. All the patients were divided,according to serum bilirubin level,into high and low groups,and their WML scores and other clinical information were compared（P〉0.05）. The odds ratios for WML were calculated using multivariate logistic regression across serum total bilirubin（P〉0.05）. Conclusion There are no association of white matter lesions with serum bilirubin level and in male elderly patients.