不对称催化亲电氟化反应研究进展

Research Progress of Asymmetric Catalytic Electrophlic Fluorination

在有机氟化学领域中,α-氟代羰基化合物具有特异的生物活性,在有机合成中也可以作为合成砌块,其合成方法学的研究是目前研究的热点和难点之一.不对称亲电氟代反应是直接构建α-氟代羰基骨架的有效方法,主要用到的催化剂包括钌、铜、钪为催化中心的金属催化剂和奎宁、手性有机磷酸为主的有机小分子催化剂.介绍了最近催化对映体选择性亲电氟化反应领域研究情况.

In the field of organic fluorine chemistry, α-fluoro carbonyl derivatives possess specific biological activity and can be used as synthetic building block in organic synthesis. The exploration of its synthetic methodology has been one of the hot and difficult spots in current scientific research. Asymmetric electrophilic fluorination is an effective method for directly constructing a-fluoro carbonyl skeleton, which mainly employs metal catalysts （ruthenium, copper, scandium） and organocatalysts （quinine, chiral phosphate）. Based on the different catalysts, the recent progress in catalytic enantioselective electrophilic fluorination was introduced.