基于DNA链置换的分子逻辑门计算模型

Calculation Model of Molecular Logic Gates Based on DNA Strand Displacement

DNA计算是近年来的研究热点,分子逻辑门是DNA计算机体系结构和运算实现的重要基础。将DNA自组装与链置换技术和荧光标记相结合,在现有的链置换逻辑计算模型的基础上,构造了非门,与门,与非门,或门和或非门。可在室温下进行,减少了因复杂的生物操作步骤带来的误差。使用荧光检测来判断逻辑结果,操作简单,容易检测,且灵敏度高。

DNA computing is a hot research topic in recent years. Molecular logic gate is an important basis of DNA computer architecture and computing implementation. By combining DNA self- assembly with strand displacement technology and fluorescence labeling,the structure of the NOT gate,AND gate,NAND gate,OR gate,NOR gate was constructed on the basis of the existing logic calculation model of strand displacement. This model was carried out at room temperature to reduce the error caused by the complex biological procedures. The fluorescence detection was used to determine the logical result,which is simple in operation,easy in detection,and of high sensitivity.