脑梗死患者血清同型半胱氨酸、叶酸及维生素B_(12)水平的分析

Analysis of serum homocysteine,folate acid and vitamin B_(12) levels in patients with cerebral infarction

目的探讨血清同型半胱氨酸(Hcy)、叶酸(FA)及维生素B12(VitB12)水平与脑梗死的关系。方法采用循环酶法和化学发光免疫法分别检测60例脑梗死患者血清Hcy、FA及VitB12水平,并与同期40例健康体检者进行比较。结果脑梗死组血清Hcy水平(23.16±8.17μmol/L)明显高于对照组(8.09±2.45μmol/L,P<0.01),血清FA水平(6.12±2.19ng/mL)和VitB12水平(323.92±133.79μmol/L)明显低于对照组(10.57±5.70ng/mL,530.85±168.56μmol/L,P<0.01)。脑梗死组血清Hcy水平与FA及VitB12水平均呈负相关(r1=-0.444,r2=-0.535,P<0.05)。结论高同型半胱氨酸血症为脑梗死的独立危险因素,与FA和VitB12水平下降有关。

Objective To investigate the correlation between the serum levels of homocysteine（Hcy）,folate acid（FA）and vitamin B12（VitB12）with cerebral infarction.Methods The enzymatic cycling method and chemiluminescence immunoassay were used to detect the serum Hcy,FA and Vit B12 levels in 60 patients with cerebral infarction,and then the detection results were compared the results of 40 people undergoing physical examination in the same period.Results The serum Hcy level in the cerebral infarction group was（23.16±8.17）μmol/L,which was significantly higher than（8.09±2.45）μmol/L in the control group（P〈0.01）,and the serum FA and Vit B12 levels in the cerebral infarction group were（6.12±2.19）ng/mL and（323.92±133.79）μmol/L,which were in the control group lower than（10.57±5.70）ng/mL and（530.85±168.56）μmol/L in the control group（P〈0.01）.The serum Hcy level in the cerebral infarction group showed the negative correlation with FA and VitB12 levels（r1 =-0.444,r2=-0.535,P〈0.05）.Conclusion High hyperhomocysteinemia is an independent risk factor of cerebral infarction and is related to the decrease of FA and VitB12.