2010~2013年本院铜绿假单胞菌的临床分布和耐药性分析

Analysis on clinical distribution and drug resistance of Pseudomonas aeruginosa in our hospital during 2010-2013

目的分析标本中铜绿假单胞菌(PAE)的临床分布和耐药情况,为临床医师用药提供指导。方法采用VITEC-2Compact全自动细菌鉴定及药敏分析系统,数据处理应用WHONET5.6软件,回顾性分析本院近4年间送检标本中PAE的检出情况、标本来源和耐药情况。结果 PAE的检出以下呼吸道标本为主,占送检标本的85%左右;对氨曲南、阿米卡星、环丙沙星、美洛培南和哌拉西林/他唑巴坦、哌拉西林、庆大霉素、头孢吡肟、头孢他啶、妥布霉素、亚胺培南、左氧氟沙星的耐药率呈逐年下降趋势,2013年除氨曲南耐药率为28.2%,其余抗菌药物均在10%左右。结论 PAE感染以呼吸道为主,及时合理监测其耐药性,为临床用药提供依据。

Objective To analyze the clinical distribution and drug resistance of Pseudomonas aeruginosa（PAE）isolated from the samples to provide the guidance for the clinician′s medication.Methods The VITEC-2Compact system automatic bacterial identification and drug susceptibility analyzer was adopted to identify the isolated bacteria and conduct the drug sensitivity test,the data were processed by the WHONET 5.6software.The PAE detection situation from the submitted specimens,source and drug resistance were performed the retrospective analysis.Results The detected PAE strains were mainly isolated from the lower respiratory tract specimens,accounting for 85 % of the submitted specimens;the resistance rate to aztreonam,amikacin,ciprofloxacin,meropenem,piperacillin/tazobactam,piperacillin,gentamicin,cefepime,ceftazidime,tobramycin,imipenem and levofloxacin showed the declining trend year by year.Except the resistant rate of aztreonam was 28.2%in 2013,which of other antibiotics were at about10%.Conclusion PAE infection is mainly in the respiratory tract,its rug resistances should be timely and reasonably monitored to provide the basis for clinical medication.