H型高血压患者血浆同型半胱氨酸水平与颈动脉粥样硬化的关系

Relationship between plasma homocysteine level and carotid atherosclerosis in H-hypertensive patients

目的探讨H型高血压患者血浆同型半胱氨酸水平与颈动脉粥样硬化的关系。方法将200例原发性高血压患者按是否合并有高同型半胱氨酸血症分为研究组(合并高同型半胱氨酸血症)和对照组。所有患者均采用GE LOGIQ3型彩色多普勒超声诊断仪检测颈部动脉,测量颈动脉内膜中层厚度(IMT)。同时所有患者均需检测血浆Hcy水平、三酰甘油、总胆固醇、高密度脂蛋白胆固醇水平及低密度脂蛋白胆固醇水平。结果 H型组的颈动脉内膜中层厚度明显高于对照组(P<0.05);且随着Hcy水平的增高,IMT逐渐增厚;颈动脉粥样硬化程度和Hcy水平明显相关(P<0.05)。结论 H型高血压患者Hcy水平与颈动脉粥样硬化密切相关。

Objective To explore the relationship between the plasma homocysteine（Hcy）level and carotid atherosclerosis in the patients with H hypertension.Methods 200 patients with essential hypertension were divided into the research group（complicating homocysteinemia）and the control group according to whether complicating homocysteinemia.Carotid artery was detected and its average intima-media thickness（IMT）was measured for all the patients by GE LOGIQ3 type color Doppler ultrasonograph.Simultaneously,the levels of plasma Hcy,triglycerides,total cholesterol,high-density lipoprotein cholesterol and low density lipoprotein cholesterol were detected.Results Average carotid IMT in the research group was significantly higher than that in the control group（P〈0.05）,and with the increase of the Hcy level,IMT was gradually thickened;in addition,the atherosclerosis degree of carotid artery was significantly associated with the Hcy level（P〈0.05）.Conclusion The Hcy level is closely related with the atherosclerosis degree of carotid artery in the patients with H hypertension.