直接药敏试验与常规药敏试验在血培养中的应用比较

Application comparison of direct drug susceptibility test and conventional drug susceptibility test in blood culture

目的评价直接药敏试验和常规药敏试验在血液细菌感染中的临床应用意义。方法随机选取2012年3月至2014年5月广州中医药大学附属新会中医院280份血培养阳性标本,对上述280份标本分别予以直接药物敏感试验和常规药敏试验,研究2种检测结果的细菌鉴定结果以及药敏结果在2种不同方法中的相关性。结果直接细菌鉴定法与常规细菌鉴定法的一致性为92.5%,2种检测方式的敏感度、药物耐药及中度敏感的符合率比较,差异无统计学意义(P>0.05)。结论直接药敏试验可以缩短血培养阳性标本的报告时间,有效指导临床合理选用抗菌药物。

Objective To evaluate the clinical application significance of the direct drug susceptibility test and the conventional drug susceptibility test in blood bacterial infection.Methods 280 specimens of positive blood culture in our hospital from March2012 to April 2014 were randomly selected and performed the the direct drug susceptibility test and the conventional drug susceptibility test.The correlation of the bacterial identification results and the drug susceptibility test results between these two kinds of method was investigated.Results The consistence of the direct bacterial identification method and bacterial identification method was 92.5%,the consistence rate of sensitivity,drug resistance and moderate sensitivity had no statistical differences between the two kinds of method（P〉0.05）.Conclusion The direct drug susceptibility test can shorten the report time of blood culture positive specimen and effectively guide the rational use of antibiotics in clinic.