脑-肠轴与炎症性肠病关系的研究进展

Relationship between braingut axis and inflammatory bowel disease

炎症性肠病(inflammatory bowel disease,IBD)包括溃疡性结肠炎(ulcerative colitis,UC)和克罗恩病(Crohn's disease,CD),是一种慢性、复发性肠道炎症性疾病.在我国,I B D发病率逐年上升.现阶段对于I B D发病机制的研究,焦点多集中于遗传易感性、免疫调节、环境、感染等方面,但其病因仍未完全明确.近期IBD神经调节机制的研究也逐渐引起学者的关注.目前,诸多研究发现脑-肠轴的心理-神经-内分泌-免疫调节在I B D的发病中起着重要的作用,探讨其他心理治疗方法可能会成为IBD重要的辅助治疗方案.本文就近年来关于脑-肠轴与IBD的研究进展进行阐述.

Inflammatory bowel disease（IBD）,including ulcerative colitis（UC） and Crohn＇s disease（CD）,is a chronic relapsing inflammatory disease affecting the gastrointestinal tract.The incidence of IBD has increased dramatically year by year in China.Currently,the IBD research is focused on genetically predisposed factors,immune response,environmental triggers and infections.However,the etiology of IBD is still unclear.Recently,more attention has been paid to the research of neural regulation affecting the progression of IBD.Previous research has revealed that psychoneuro-endocrine-immune modulation through the brain-gut axis plays a crucial role in the pathogenesis of IBD.It is important to explore other psychotherapies applied to adjutant therapy in IBD.This review reviews the recent advances in understanding the relationship between the brain-gut axis and inflammatory bowel disease.