血清瘦素水平与肝癌相关性的Meta分析

Meta-analysis of association between serum leptin and hepatocellular carcinoma risk

目的:采用Meta分析法探讨血清瘦素水平与肝癌发病的相关性.方法:以肝癌组和对照组人群血清瘦素水平m e a n±S D为效应指标,根据异质性检验的结果,选择随机效应模型对mean±SD进行合并并进行偏倚评估.结果:共查到符合要求的国内外文献335篇,病例和对照数分别为646例、457例.经异质性检验,10项研究结果存在异质性(q=556.71,P<0.00001),经过随机效应模型估计,肝癌患者血清瘦素水平的合并OR值为(2.11,95%C I:0.84-3.38).按放射免疫分析法(radioimmunoassay,RIA)、酶联免疫吸附法(enzyme-linked immunosorbent assay,E L I S A)2种检测方法分层分析后合并O R值为(2.28,95%CI:0.89-3.67)和(2.41,95%CI:0.36-4.46),OR值较一致.结论:肝癌患者血清瘦素水平偏高,瘦素可能增加了肝癌发病的风险.

AIM：To assess the association between serum leptin and hepatocellular carcinoma risk.METHODS：Taking into account the possibility of heterogeneity test,a random effects model was used to calculate mean ± standard deviation of association strength between serum leptin and hepatocellular carcinoma risk.Publication bias was also evaluated.RESULTS：A total of 646 cases and 457 controls from 335 studies were included.There was heterogeneity in these studies after test of heterogeneity（q = 556.71,P 0.00001）.The combined odds ratio（OR） values of radioimmunoassay（RIA） and enzyme-linked immunosorbent assay（ELISA） were 2.28（95%CI：0.89-3.67） and 2.41（95%CI：0.36-4.46）,respectively,and the OR values were consistent.CONCLUSION：Serum leptin is higher in hepatocellular carcinoma patients,and it may increase the risk of hepatocellular carcinoma.