趋化因子及其受体与冠心病关系的研究进展

Research progress in the relationship between chemokines and their re-ceptors and coronary heart disease

动脉粥样硬化(AS)是慢性炎性及代谢性疾病,脂质沉积和炎性细胞浸润至血管内皮下是形成AS的主要原因,但是炎性细胞浸润的机制尚未阐明。许多国内外研究表明,趋化因子对单核细胞、巨噬细胞、T细胞等炎性细胞的迁移、活化在AS炎症反应中起重要作用。新近研究证实,趋化因子可促使血管平滑肌细胞增殖以及炎症因子和基质金属蛋白酶的合成,促进斑块不稳定的关键环节。本文就趋化因子及其受体在AS发生发展中的作用予以综述。

Atherosclerosis（ AS） is a chronic inflammatory condition. The main causes for AS formation are metabolic diseases,lipid deposition and infiltration of inflammatory cells to the vascular endothelium;however,the mechanism of inflammatory infiltration has not yet been elucidated. Many national and international studies have shown that migration and activation of chemokines to monocytes,macrophages,T cells and other inflammatory cells are important in the inflammatory response of AS. Recent studies have demonstrated that chemokines may promote the proliferation and synthesis of inflammatory cytokines and matrix metalloproteinases cells,promoting plaque instability. This article briefly reviews the functions of chemokines and their receptors in AS.