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蛋白酶3及其与疾病的关系研究进展 被引量：5

Research Advances on Proteinase 3 and Its Relationship With Diseases
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摘要 蛋白酶3(proteinase 3,PR3)是中性粒细胞分泌的主要丝氨酸蛋白酶之一,其生物学功能广泛,不仅能降解多种组织蛋白,还可通过加工细胞因子、受体等调控炎症反应,与慢性炎症性疾病如血管炎性肉芽肿病、慢性阻塞性肺疾病、肺囊肿性纤维症的发生发展密切相关,可能作为疾病防治靶点.本文主要综述了PR3的生物学功能及其在疾病中的可能作用机制,期望为相关疾病的防治提供新的思路. Proteinase 3 is one of the major serine proteases secreted by neutrophils with multiple biological functions. It can degradate tissue proteins, process cytokines and receptors, thus contributing to the regulation of inflammatory and immune responses, and play important roles in the occurrence and development of chronic inflammatory diseases, such as granulomatosis with polyangiitis, chronic obstructive pulmonary diseases and pulmonoary fibrosis. In this reviews, we describle the biological functions of PR3 and its roles in human diseases,which might provide a new insight for the prevention and treatment of human diseases.
作者 刘广花 邓莉 彭礼飞
机构地区 广东省医学分子诊断重点实验室 广东医学院寄生虫学和临床寄生虫检验学教研室
出处 《生物化学与生物物理进展》 SCIE CAS CSCD 北大核心 2015年第3期244-253,共10页 Progress In Biochemistry and Biophysics
基金 国家自然科学基金(81171599) 广东省高等学校科技创新项目(2013KJCX0087) 广东医学院科技创新团队项目(STIF201107)资助~~
关键词 蛋白酶3 细胞因子 抑制剂 炎症性疾病 血管炎性肉芽肿病 慢性阻塞性肺疾病 肺囊肿性纤维症 proteinase 3 cytokine inhibitor inflammatory disease granulomatosis with polyangiitis chronic obstructive pulmonary diseases pulmonary diseases, pulmonoary fibrosis
分类号 Q5 [生物学—生物化学] R3 [医药卫生—基础医学]
  • 相关文献

参考文献65

  • 1邓振,何庆丰,彭礼飞.中性粒细胞丝氨酸蛋白酶及其抑制剂与炎症[J].中国药理学通报,2014,30(3):18-21. 被引量：16
  • 2Korkmaz B, Hajjar E, Kalupov T, et al. Influence of charge distribution at the active site surface on the substrate specificity of human neutrophil protease 3 and elastase. A kinetic and molecular modeling analysis. J BioI Chern, 2007, 282(3): 1989-1997.
  • 3Hajjar E, Broemstrup T, Kantari C, et al. Structures of human proteinase 3 and neutrophil elastase--so similar yet so different. FEBS J, 2010, 277(10): 2238-2254.
  • 4Owen C A. Leukocyte cell surface proteinases: regulation of expression, functions, and mechanisms of surface localization. Int J Biochem Cell BioI, 2008, 40(6-7): 1246-1272.
  • 5Korkmaz B, Jaillet J, Jourdan M L, et al. Catalytic activity and inhibition of wegener antigen proteinase 3 on the cell surface of human polymorphonuclear neutrophils. J Bioi Chern, 2009, 284(30): 19896-19902.
  • 6Kuckleburg C J, Tilkens S B, Santoso S, et al. Proteinase 3 contributes to transendothelial migration of NB l-positive neutrophils. J Immunol, 2012, 188(5): 2419-2426.
  • 7Kantari C, Pederzoli-Ribeil M, Amir-Moazami 0, et al- Proteinase 3, the Wegener autoantigen, is externalized during neutrophil apoptosis: evidence for a functional association with phospholipid scramblase 1 and interference with macrophage phagocytosis. Blood,2007,110(12):4086-4095.
  • 8Tongaonkar P, Golji A E, Tran P, et al. High fidelity processing and activation of the human a-defensin HNPI precursor by neutrophil elastase and proteinase 3. PloS one, 2012,7(3): e32469.
  • 9Kim Y C, Shin J E, Lee S H, et al. Membrane-bound proteinase 3 and P AR2 mediate phagocytosis of non-opsonized bacteria in human neutrophils. Mol Immunol, 2011, 48(15-16): 1966-1974.
  • 10Heinz A, lung M C, Jahreis G, et al. The action of neutrophil serine proteases on elastin and its precursor. Biochimie, 2012, 94 (l): 192-202.

二级参考文献30

  • 1Heutinck K M,ten Berge I J,Hack C E,et al.Serine proteases of the human immune system in health and disease[J].Mol Immunol,2010,47(11-12):1943-55.
  • 2Steven S D.Neutrophil elastase:path clearer,pathogen killer,or just pathologic[J]-.Am J Respir Cell Mol Biol,2002,26(3):266-8.
  • 3Jochum M,Gippner-Steppert C,Machledit W,et al.The role of phagocyte proteinases and proteinase inhibitors in multiple organ failure[J].Am J Respir Crit Care Med,1994,150 (6 Pt 2):S123-30.
  • 4Burster T,Macmillan H,Hou T,et al.Cathepsin G:roles in antigen presentation and beyond[J].Mol Immunol,2010,47:658-65.
  • 5Gregory A D,Houghton A M.Tumor-associated neutrophils:new targets for cancer therapy[J].Cancer Res,2011,71(7):2411-6.
  • 6Hajjar E,Broemstrup T,Kantari C,et al.Structures of human proteinase 3 and neutrophil elastase-so similar yet so different[J].FEBS J,2010,277(10):2238-54.
  • 7Perera N C,Schilling O,Kittel H,et al.NSP4,an elastase-related protease in human neutrophils with arginine specificity[J].Proc Natl Acad Sci USA,2012,109(16):6229-34.
  • 8Perera N C,Jenne D E.Perspectives and potential roles for the newly discovered NSP4 in the immune system[J].Expert Rev Clin Immunol,2012,8(6):501-3.
  • 9Chalmers J D,Hill A T.Mechanisms of immune dysfunction and bacterial persistence in non-cystic fibrosis bronchiectasis[J].Mol Immunol,2013,55(1):27-34.
  • 10Lucas S D,Costa E,Guedes R C,et al.Targeting COPD:advances on low-molecular-weight inhibitors of human neutrophil elastase[J].Med Res Rev,2013,33(Suppl 1):E73-101.

共引文献15

同被引文献41

  • 1任翠平,王晓楠,雷黎,朱绍春,赵志荣,刘淼,沈际佳.血吸虫感染抗性人血清筛选日本血吸虫童虫cDNA文库[J].中国地方病学杂志,2007,26(5):490-493. 被引量：2
  • 2Johnson JL, Devel L, Czarny B, et al. A selective matrix metal- loproteinase-12 inhibitor retards atherosclerotic plaque develop- ment in apolipoprotein E-knockout mice [J]. Arteriosclerosis, Thrombosis, and Vascular Biology, 2011, 31(3): 528-535.
  • 3Trivedi V, Boire A, Tchernychev B, et al. Platelet matrix metal- loprotease-1 mediates thrombogenesis by activating PAR1 at a cryptic ligand site[J]. Cell, 2009, 137(2): 332-343.
  • 4Cavusoglu E, Marmur JD, Hegde S, et al. Relation of baseline plasma MMP-1 levels to long-term all-cause mortality in pa- tients with known or suspected coronary artery disease referred for coronary angiography[J]. Atherosclerosis, 2015, 239(1): 268-275.
  • 5Shin DH, Diet U, Melendez JA, et al. Regulation of MMP-1 ex- pression in response to hypoxia is dependent on the intracellularredox status of metastatic bladder cancer cells[J]. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 2015, 1852(1 2593-2602.
  • 6Elkington P, Shiomi T, Breen R, et al. MMP-1 drives im- munopathology in human tuberculosis and transgenic mice [J]. The Journal of Clinical Investigation, 2011, 121(5): 1827-1831.
  • 7Wang F, Fisher J, Fishman DA. MMP-1-PAR1 axis mediates LPA-induced epithelial ovarian cancer (EOC) invasion[J]. Gyne- cologic Oncology, 2011, 120(2): 247-255.
  • 8Sch ti tz A, Rtiser K, Klitzsch J, et al. Lung adenocarcinomas and lung cancer cell lines show association of MMP-1 expres- sion with STAT3 activation[J]. Translational oncalogy, 2015, 8(2): 97-105.
  • 9Lin BC, Du X, Wang QR, et al. MMP-1 and pro-MMP-10 as potential urinary pharmacodynamic biomarkers of FGFR3-targeted therapy in patients with bladder cancer[J]. Cancer Research, 2014, 20(24): 6324-6335.
  • 10Weiss MB, Abel V, Mayberry MM, et al. TWIST1 is an ERK1/2 effector that promotes invasion and regulates MMP-1 expression in human melanoma cells[J]. Cancer Research, 2012, 72(24): 6382-6392.

引证文献5

二级引证文献33

生物化学与生物物理进展
2015年 第3期

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