肺癌患者术后肺部感染血清降钙素原与白细胞介素的变化研究

The research of the changes of serum procalcitonin and interleukin in lung cancer patients with pulmonary infections after the operation

目的探讨肺癌患者术后肺部感染血清降钙素原(PCT)及白细胞介素(IL)的变化,为临床治疗提供参考依据。方法选择2013年1月-2014年1月200例肺癌患者,将其中肺部感染的108例患者作为感染组,92例肺癌无肺部感染患者作为对照组,测定两组患者血清PCT、IL及体温,根据感染组中患者转归,分为生存组80例与死亡组28例,分析生存组与死亡组治疗前,治疗第2、4天及死亡前或者痊愈后血清PCT、IL值变化。结果感染组患者血清PCT、IL值以及体温分别为(18.26±7.48)ng/ml、(35.1±13.0)μg/L、(40.4±1.0)℃,与对照组血清PCT(3.56±1.02)ng/ml、IL(4.3±1.4)μg/L、体温(37.0±1.2)℃比较均明显升高,差异有统计学意义(P<0.01);生存组与死亡组治疗前血清PCT、IL值差异无统计学意义。结论血清PCT、IL值水平的测定对肺癌患者术后肺部感染有较好的预警价值,是诊断肺部感染的敏感指标,可以作为诊断或者知道治疗肺部感染的辅助性指标,具有较高的临床价值。

OBJECTIVE To investigate the changes of serum PCT and interleukin（IL）in lung cancer patients with pulmonary infections after the operation so as to provide references for clinical treatments.METHODS Totally 200 cases of lung cancer patients from Jan.2013 to Jan.2014 were chosen.Among them,108 patients of pulmonary infection were set as the infection group,and the other 92 cases of lung cancer patients without lung infection were set as the control group.The serum PCT level,IL level and the patient＇s body temperature were measured.According to the recovery conditions of the infection group,108 patients were divided into the survival group with 80 cases and the death group with 28 cases.The changes of serum PCT and IL in the survival and death groups before the treatment,and the 2and 4days after the treatment,before the death or after recovery were taken for analysis.RESULTS The value of serum PCT,IL and the average temperature for the infection group were（18.26±7.48）ng/ml,（35.1±13.0）μg/L,and（40.4±1.0）℃ respectively and compared with the control group with serum PCT（3.56±1.02）ng/ml,IL（4.3±1.4）μg/L,body temperature（37.0±1.2）℃,they were significantly higher（P〈0.01）.The differences of serum PCT,IL value of the survival and death groups were without significance.CONCLUSIONThe measurement of serum PCT and IL values has better warning effect for postoperative pulmonary infection in patients with lung cancer,and it is a sensitive indicator of the diagnosis of pulmonary infections.It can be used as the secondary indicators for diagnosing or knowing pulmonary infections,and it is with high clinical value.