血清炎性因子与老年冠心病患者肺炎衣原体感染的相关性分析

Correlation analysis of serum inflammatory factors and Chlamydia pneumoniaeinfection in elderly patients with coronary heart disease

目的探讨血清超敏C-反应蛋白、白介素-6与老年冠心病患者肺炎衣原体感染的相关性,探讨冠心病的可能致病机制,为诊断和治疗提供参考依据。方法选取2013年4月-2013年12月冠心病患者57例及同期健康体检者60名分别作为观察组和对照组,采集两组人员空腹静脉血行实验室检查,并进行比较,采用SPSS13.0软件进行统计分析。结果观察组IgG滴度及阳性率为1.70±0.28及84.21%、对照组为1.51±0.22及48.33%,两组比较差异有统计学意义(P<0.05),观察组患者TNF-α、IL-6、hsCRP以及Fg水平均明显高于对照组,两组比较差异有统计学意义(P<0.05);观察组IgG阳性患者TNF-α、hsCRP以及Fg水平均明显高于阴性者,二者比较差异有统计学意义(P<0.05)。结论肺炎衣原体感染与冠心病发生和发展有一定的相关性,对感染肺炎衣原体的冠心病患者检测血清hsCRP及IL-6水平,可以早期诊断、提高患者的治疗效果。

OBJECTIVE To investigate correlation of serum high-sensitive C-reactive protein（hsCRP）,interleukin-6（IL-6）and Chlamydia pneumoniae infections in elderly patients with coronary heart disease and explore the pathogenesis of coronary heart disease so as to provide a basis for diagnosis and treatment.METHODS Totally 57 patients with coronary heart disease during Apr.2013 to Dec.2013 and 60healthy people during the same period were enrolled as the observation group and the control group.Fasting blood was collected from the two groups for laboratory tests and the test result was compared.The software SPSS13.0 was used for statistical analysis.RESULTS The IgG titer and the IgG positive rate were 1.70 ± 0.28 and 84.21% in the observation group and were 1.51±0.22 and 48.33%in the control group（P〈0.05）.TNF-α,IL-6,hsCRP and fibrinogen（Fg）levels were significanely higher in the observation group than in the control group（P〈0.05）.TNF-α,hsCRP and Fg levels were significantly higher in the IgG-positive patients than in the IgG-negative patients in the observation group（P〈0.05）.CONCLUSION C.pneumoniae infection has certain relevance with the onset and the development of coronary heart disease.Detection of serum hsCRP and IL-6levels for C.pneumoniae infected patients with coronary heart disease is helpful for early diagnosis and improvement of treatment outcomes.