聚维酮碘皮肤消毒预防白内障手术感染的研究

Povidone iodine for skin disinfection to prevent infections in cataract surgery

目的探讨采用0.5%聚维酮碘对眼周皮肤消毒预防白内障术后感染的临床疗效,为临床治疗提供参考依据。方法选取1 200例、1 500眼2012年1月-2013年12月就诊的有白内障手术指征的患者作为研究对象,随机分成试验组和对照组,每组750眼;试验组在清洁擦拭后,用0.5%聚维酮碘消毒,对照组仅用消毒棉签消毒;观察患者有无眼内炎的发生,并嘱患者填写眼部不适情况调查表。结果试验组750眼均未发生眼内感染,对照组750眼中发生眼内炎7眼,其发生率为0.93%,试验组的感染发生率明显低于对照组,差异有统计学意义(P<0.05);试验组术后异物感、刺痛感的发生率低于对照组,差异有统计学意义(P<0.05)。结论对白内障患者术后采用0.5%聚维酮碘进行眼周皮肤消毒,可以降低术后感染的发生,同时还能够减少术后眼部的不适感,安全性良好、临床疗效满意。

OBJECTIVE To investigate the clinical efficacy of infection prevention by using 0.5% povidone iodine for disinfection of the skin around the eye after cataract surgery so as to provide reference for clinical treatment.METHODS Totally 1200 cases of 1500 eyes of patients with cataract surgical indications from Jan.2012 to Dec.2013 for treatment were randomly divided into two groups,the experimental group and the control group with 750 eyes in each group.The experimental group was disinfected with 0.5% povidone iodine after cleaning wipe test,while the control group used only a sterile cotton swab to wipe and clean the skin around the eye.Patients were observed for the incidence of endophthalmitis,and patients were asked to fill out the questionnaire about eye discomfort.RESULTS None of the 750 eyes in the experimental group had intraocular infection,while 7out of 750 eyes in the control group had endophthalmitis with the incidence rate of 0.93%,indicating that the incidence of infection in the experimental group was significantly lower than the control group（P〈0.05）.The incidence of foreign body sensation and tingling in the experimental group was significantly lower than the control group（P〈0.05）.CONCLUSION Application of 0.5% povidone iodine disinfection of skin around the eye for postoperative cataract patients can reduce the incidence of postoperative infection,also can reduce postoperative ocular discomfort,which can achieve good safety and satisfactory clinical outcomes.