卵巢储备功能下降相关因素的logistic回归分析

Logistic regression analysis of related factors on diminished ovarian reserve

目的：探讨导致卵巢储备功能下降（DOR）的相关因素。方法：选取2012年5月~2014年5月在天津市中心妇产科医院生殖医学中心接受常规体外受精（IVF）或卵胞浆内单精子注射（ICSI）治疗的卵巢储备功能下降患者200例和非DOR患者200例（对照组）。采用logistic回归分析方法分析患者年龄、体重指数（BMI）、不孕年限、吸烟史、染色体、痛经史、初潮年龄、月经周期、经期、孕次、初次性生活、初次妊娠年龄、人流次数、药流次数、子宫内膜异位症、手术史、雄激素水平、血型、促排卵次数与DOR的关系。结果：最终进入logistic回归模型参数包括人流次数（OR=2.329）、促排卵次数（OR=9.578）、子宫内膜异位症史（OR=5.836）、初潮年龄（OR=0.318）、手术史（OR=3.409）。结论：人流次数、促排卵次数、子宫内膜异位症病史及手术史均为DOR危险因素,初潮年龄为DOR保护因素。

Objective： To analyze the related factors on diminished ovarian reserve.Methods： From May 2012 to May 2014 200 women with DOR（ DOR group） and 200 non-DOR（ control group） received conventional in vitro fertilization and intracytoplasmic sperm injection in the treatment of infertility in Tianjin Central Hospital of Obstetrics and Gynecology,Center for Reproductive Medicine. Logistic regression analysis was used to evaluate the relationship among age,BMI,time of infertility,smoking,chromosome,dysmenorrheal,age at menarche,menstrual cycle,menstrual period,gravidity frequency,age of first sexual life,age of first pregnancy,abortion and drug abortion frequency,endometriosis,surgical history,the level of testosterone,blood type,the frequency of ovulation and DOR. Results： Variables in the equation of logistic regression were abortion frequency（ OR = 2. 329）,the frequency of ovulation（ OR = 9. 578）,endometriosis（ OR = 5. 836）,age at menarche（ OR = 0. 318）,surgical history（ OR = 3. 409）. Conlusion： Abortion frequency,the frequency of ovulation,endometriosis,surgical history are the risk factors on DOR and age at menarche are the protective factors.