细辛脑与氨溴索雾化吸入辅助治疗肺部感染疗效比较

The comparison of curative effect of aerosol inhalation between asarone and ambroxol hydrochloride in pul-monary infection

目的：比较细辛脑与氨溴索雾化吸入辅助治疗肺部感染的疗效。方法将99例肺部感染患者按照入院顺序号随机分为A、B、C三组，每组均为33例。在常规治疗的基础上，A组行细辛脑加0．9％氯化钠注射液超声雾化治疗；B组行氨溴索加0．9％氯化钠注射液超声雾化吸入；C组为对照组，行糜蛋白酶加0.9％氯化钠注射液雾化治疗。持续治疗3～5 d，记录三组治疗后咳嗽、气促消失时间，体温恢复正常时间，肺部啰音消失时间及住院时间。在治疗结束时进行疗效判定。结果治疗后，A组咳嗽气促消失时间、体温恢复正常时间、住院时间、肺部啰音消失时间分别为（4．30±1．55）d、（2．93±0．89）d、（4．44±1．67）d、（5．66±1．72）d，B组分别为（4．34±1．83）d、（3．10±0．77）d、（4．52±1．58）d、（5．82±1．76）d，C组分别为（6．11±1.49）d、（3．98±1．01）d、（6．22±1．92）d、（7．52±1．56）d，A、B两组咳嗽气促消失时间、体温恢复正常时间、肺部啰音消失时间和住院时间差异均无统计学意义（均P＞0．05），A组咳嗽气促消失时间、体温恢复正常时间、肺部啰音消失时间、住院时间均显著短于C组（t＝4．836、4．481、4．018、4．601，均P＜0．05），B组咳嗽气促消失时间、肺部啰音消失时间、住院时间均显著短于C组（t＝4．309、3．980、3．927、4．152，均P＜0．05）；A组和B组总有效率分别为90．9％和87．8％，均显著高于C组的69．7％（χ2＝26．753、24．685，P＝0．000），A组与B组总有效率差异无统计学意义（χ2＝1．128，P＝0．288）。结论细辛脑和氨溴索雾化吸入辅助治疗肺部感染均具有较好的疗效。在临床实践中，宜结合患者具体情况加以选择药物。

Objective To compare the curative effect on pulmonary infection between asarone and muco -solvin.Methods 99 cases with pulmonary infection were randomly divided into A ,B,C three groups with each group of 33 patients according to the order of admission .On the basis of conventional therapy ,A group were received the ultrasonic nebulization therapy of asarone plus 0.9%sodium chloride injection ,B group were received the ultrasonic nebulization therapy of mucosolvin plus 0.9% sodium chloride injection ,C group was treated based on the control group received the ultrasonic nebulization therapy of chemotropism plus 0.9% sodium chloride injection treatment . The time of cough and anhelation turnaround ,the time of body temperature returned to normal ,the time of pulmonary rales disappearance and hospitalization time .The curative effects were judged at the end of treatment .Results After treatment,A group of cough,shortness of breath disappearance time,temperature returned to normal time,hospital stay,pulmonary rales disappearance time was （4.30 ±1.55）d,（2.93 ±0.89）d,（4.44 ±1.67）d,（5.66 ±1.72）d, respectively,in group B （4.34 ±1.83）d,（3.10 ±0.77）d,（4.52 ±1.58）d,（5.82 ±1.76）d,C group were （6.11 ±1.49）d, （3.98±1.01）d,（6.22±1.92）d,（7.52 ±1.56）d,A,B groups cough,shortness of breath disappear time,body tem-perature returned to normal , pulmonary rales disappeared time and hospital stay were not significantly different （ all P〉0.05）,A group of cough,shortness of breath disappearance time,body temperature returned to normal,pulmonary rales disappeared time,length of hospital stay were significantly shorter than group C （t =4.836,4.481,4.018, 4.601,all P〈0.05）,B groups cough,shortness of breath disappear time,pulmonary rales disappeared time,length of hospital stay were significantly shorter than those of group C （t=4.309,3.980,3.927,4.152,all P〈0.05）;A group and B group total efficiency of 90.9%and 87.8%,respectively,which were significantly higher than 69.7%group C （χ2 =26.753,24.685,P=0.000）,A group and B group total efficiency difference was not statistically significant（χ2 =1.128,P=0.288）.Conclusion Asarone and mucosolvan have the similar curative effect in the treatment of pulmonary infection .It should be combined with the specific situation of patients to choose drugs in clinical practice .