肠道菌群生态失衡与肠易激综合征

Ecological Imbalance of Intestinal Flora and Irritable Bowel Syndrome

肠易激综合征(IBS)的发病机制尚未完全明了,可能与多种因素有关。IBS时存在肠道菌群生态失衡,早在20世纪80年代即已提出此种失衡可能与IBS的发生有关。新近研究发现对于感染后IBS(PI-IBS),以益生菌恢复肠道菌群正常比率可取得显著疗效,证实肠道菌群在IBS的发病机制中起重要作用。本文就肠道菌群生态失衡与IBS的关系以及相关治疗进展作一综述。

The pathogenesis of irritable bowel syndrome（ IBS） is not fully clear,and might be associated with various factors. In 1980 s,correlation between ecological imbalance of intestinal flora and IBS was raised. Recently,remarkable efficacy was observed in the treatment of post-infectious IBS（ PI-IBS） by re-balancing the intestinal flora with probiotics.Thus it was proved that intestinal flora might play an important role in the pathogenesis of IBS. In this article,the association between ecological imbalance of intestinal flora and IBS as well as the related treatment strategies were reviewed.