聚十二碳烯整体柱的制备及其对小分子的分离

Preparation of poly dodecene monolithic column for HPLC separations of small molecules

以1-十二碳烯(C12)作为反应单体,以三羟甲基丙烷三丙烯酸酯(TMPTA)和乙二醇二甲基丙烯酸酯(EDMA)为交联剂,以偶氮二异丁腈(AIBN)为引发剂通过自由基原位聚合制备了有机聚合物整体柱.通过电子扫描显微镜、红外光谱等方法分别对其内部结构、官能团进行了表征,并且对通透性进行了研究.结果表明,该整体柱结构较均匀,且渗透性良好.将该整体柱作为高效液相色谱的固定相对小分子进行了分离,取得了较好的分离效果.

A novel hydrophobic polymeric monolith was prepared by using 1 -dodecene（C12） as the functional monomers, trimethylol propane triacrylate（TMPTA） and ethylene dimethacrylate （EDMA） as the cross-linking agent, 2,2＇-azobisisobutyronitrile （AIBN） as the initiator; The chemical group of the monolithic column was confirmed by a Fourier transform infrared spectroscopy （FT - IR） method and the morphology of column structure was characterized by scanning electron microscopy （SEM）. The permea- bility was also studied. The resulting monolith showed a relatively homogeneous structure and good per- meability. The monolith was used to separate small molecules and a good result has been obtained.