血浆脑钠肽前体检测对心源性脑栓塞的诊断价值

Diagnostic value of plasma pro-brain natriuretic peptide in cardioembolic ischemic stroke

目的：探讨血浆脑钠肽前体（Pro-brain natriuretic peptide,Pro-BNP）检测对心源性脑栓塞（Cardioembolic,CE）诊断价值。方法：连续登记2013年10月~2014年1月我院神经内科收住的92例急性脑梗死（Cerebral infarction,CI）患者,检测患者血浆Pro-BNP水平,根据TOAST诊断标准分为CE组（n=38）和非CE组（n=54）,比较两组血浆Pro-BNP水平差异性。结果：CI组患者血浆Pro-BNP水平明显高于正常对照组（中位数413.1 vs 68.06,P〈0.01）;CE组血浆Pro-BNP水平明显高于非CE组（中位数1 618 vs 121.9,P〈0.01）。结论：血浆Pro-BNP水平检测有助于脑梗死病因学分型,有利于早期开展脑梗死二级预防治疗。

Objective： To assess the diagnostic value of plasma pro-brain natriuretic peptide（ Pro-BNP） in cardioembolic ischemic stroke. Methods： Consecutive 92 patients with cerebral infarction（ CI） admitted to our department were included from October 2013 through January 2014,and allocated to cardioembolic（ CE） group（ n = 38） and non-cardioembolic（ non-CE） group（ n = 54） according to TOAST criteria. The two groups of patients were undergone comparison of the Pro-BNP levels measured. Results： The Pro-BNP level in CI group was significant higher than that of normal control group（ median 413. 1vs. 68. 06,P〈 0.01）,and higher Pro-BNP levels were also observed in CE group as compared with non-CE group（ median 1 618 vs. 121. 9,P〈 0.01）.Conclusion： Measurement of Pro-BNP level may contribute to clarifying the etiologic subtypes of cerebral infarction and its early prevention and treatment.