复方阿胶浆改善恶性肿瘤患者生活质量的临床研究

Clinical Study on the Effect of Fufang E-jiao Jiang(FEJ) on the Improvement of the Quality of Life of Cancer Patients

目的观察复方阿胶浆口服液对恶性肿瘤中晚期患者贫血的疗效,为患者提供合理的治疗方案,提高恶性肿瘤患者生活质量,延长生存期。方法采用随机对照临床试验研究原则,将66例气血两虚型中晚期肿瘤患者分为试验组和对照组,每组各33例;对照组给予基础抗贫血治疗。治疗组在对照组的基础上加用复方阿胶浆口服液。两组病例观察时间均以28天为观察周期。通过观察患者治疗后贫血改善情况,临床症状以及患者生存质量情况进行综合分析、科学评价。结果治疗组贫血疗效总效率为75.6%;对照组总有效率为51.5%,治疗组的总有效率明显优于对照组。治疗组中医症状积分总有效率为100%,对照组总有效率为69.7%,治疗组中医症状改善情况明显优于对照组。治疗组KPS评分改善总稳定率为100%,而对照组总稳定率为75.6%,治疗组KPS评分情况改善优于对照组。两组在治疗前后安全性指标经统计学处理没有显著性差异,表明复方阿胶浆对心、肝、肾功能无损害。结论结果证实复方阿胶浆能显著提高气血两虚型中晚期肿瘤患者的血红蛋白及白细胞,并改善临床症状,提高KPS评分,从而提高患者的生活质量。

Objective ： To observe the clinical effect of Fufang E -jiao Jiang（FEJ） oral solution on the treatment of middle - late malignant cancer patients with anemia and provide patients with appropriate treatment programs to im- prove the quality of their life and prolong their survival. Methods： 66 patients were randomly divided into a test group and a control group, 33 patients per group. The control group was given basic anti - anemia treatment while the testgroup was added with FEJ oral solution besides the basic anti -anemia treatment. 28 days was an observation period for both groups. Through the observation of their anemia improvement, a comprehensive analysis and a scientific evalu- ation of the clinical symptoms and the life quality of the patients have been made after the treatment. Results ： The total effective rate of the anemia treatment of the test group was 75.6% while that of the control group was 51.5%. The to- tal effectiveness of the test group was better than that of the control group. The total stable rate of TCM symptom score of the test group was 100% while that of the control group was 69. 7%. The clinical symptoms of the test group im- proved batter than that of the control group. The total stable rate of KPS scores of the test group was 100% while that of the control group was 75.6%. The KPS scores of the test group improve better than that of the control group. The safety indicators of the two groups before and after the treatment were no statistically significant difference, indicating FEJ had no impairment to heart, liver and renal function. Conclusion： The results confirm FEJ can significantly in- crease the hemoglobin and hemameba of the patients and improve their clinical symptoms and raise their KPS scores, thereby improving the quality of life of the patients.