差示分光光度法测定复方多潘立酮黏附漂浮片释放度

Determination of Drug Release Rate of the Compound Domperidone Floating-bioadhesive Tablet by Differential Spectrophotomety

目的：建立复方多潘立酮黏附漂浮片释放度的测定方法,进以控制该控释片的质量。方法：以人工胃液作释放介质,以差示分光光度法测定在300 nm和326 nm两波长下的吸收值。结果：辅料对药物及药物之间测定无干扰。在300 nm处,多潘立酮线性范围为4.91-24.56μg/mL（r=0.9993）,平均回收率为100.5%,RSD=0.99%。在326 nm处,维生素VB6线性范围为8.11-40.56μg/mL（r=0.9991）,平均回收率为100.5%,RSD=0.79%。结论：差示分光光度法为本制剂提供了简便、快速、准确的检测方法。

Objective：To establish a detecting methed for the dislution of the compound tablet to control the quality of this tablet. Methods：The artificial gastric juices as release medium,to determine the absorptions of 300 nm and 326 nm the differential spectrophotomety. Results：Auxiliary materials for drugs and drugs between to determine no interfereence.At 300 nm,the linear range of Domperidone was 4.91-24.56 μg/m L（r=0.9993）,The average recovery ratew as 100.5%,and RSD was 0.99%.At 326 nm,the linear range of vitamin B6 was 8.11~40.56 μg/m L（r=0.9991）,The average recovery ratew as 100.5%,and RSD was 0.79%. Conclusion：The differential spectrophotomety is convenient,rapid and accurate.