终末期肾脏病患者鼻测口臭相关影响因素的Logistic回归分析

Analysis of the influence factors and clinical indices for halitosis in end-stage renal disease patients through multiple logistic regression

目的探讨终末期肾脏病(ESRD)患者口臭与相关影响因素的关系。方法分别用茚三酮分光光度法和鼻测法检测ESRD患者口气中氨的浓度值和感官口气值(OS),并统计性别、年龄、学历、透析时间、抽烟史、氨值、肌酐、尿素氮、唾液pH值、舌苔面积、舌苔厚度等因素,分析鼻测法与这些检测指标之间的Logistic回归关系。结果在α=0.05水平,单因素Logistic回归分析显示氨值、尿素氮、舌苔厚度、唾液pH值等4个因素为ESRD患者口臭的危险因素,进一步作多因素Logistic回归分析表明,氨值是ESRD患者口臭最可能的危险因素。结论 SRD患者体内不能完全代谢的氨是产生氨性口臭最可能的危险因素。

Objective To study the relationship between the influence factors and halitosis in end-stage renal disease（ESRD） patients. Methods Organoleptic scores（OS） and concentration value of ammonia were measured independently by organoleptic assessment and ninhydrin spectrophotometry.Factors such as gender, age, education, duration of dialysis, smoking history, ammonia, urea nitrogen, creatinine, salivary pH, area and thickness of tongue coating were statistically analyzed. The Logistic regression relationship of oroganolepticscores and other clinical indices was studied. Results At the level of α=0.05, the single factor Logistic regression analysis showed that four factors including the ammonia, urea nitrogen, the thickness of tongue coating and salivary pH were the risk factors of halitosis in patients with end stage renal disease. Further multivariate Logistic regression analysis showed that ammonia was the most possible risk factor of halitosis in patients with end stage renal disease.Conclusion Ammonia not completely metabolized in the body of patients with end stage renal disease is the most possible risk factor of halitosis in these patients.